上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）抗结核分枝杆菌药 Antimycobacterial drugs、抗麻风病药 antileprotic drugs

上泽充通大学 Shanghai Jiao Tong Univer. Antimycobacterial drugs(抗结核 分枝杆菌药) and antileprotic drugs(抗麻风病药) 2011.12

Antimycobacterial drugs（抗结核 分枝杆菌药） and antileprotic drugs（抗麻风病药） 2011.12

上游充通大￥ Mycobacterium tuberculosis 后 Shanghai Jiao Tong University 亦称结核杆菌：结核分枝杆菌（M tuberculosis),牛分枝杆菌(M.bovis) waxy coating (primarily mycolic acid) M.tuberculosis bacterial colonies

Shanghai Jiao Tong University Mycobacterium tuberculosis 亦称结核杆菌: 结核分枝杆菌（M. tuberculosis), 牛分枝杆菌(M. bovis) M. tuberculosis bacterial colonies waxy coating (primarily mycolic acid)

上商充通大￥ Shanghai Jiao Tong University Mycobacterium tuberculosis (stained red)in tissue (blue)

Shanghai Jiao Tong University Mycobacterium tuberculosis (stained red) in tissue (blue)

上商充通大￥ 形态与染色 Shanghai Jiao Tong University 圈细长略带弯曲，分枝状，有荚膜，抗酸染色阳性

Shanghai Jiao Tong University 形态与染色 细长略带弯曲，分枝状，有荚膜，抗酸染色阳性

上浒充通大学 Tuberculosis-related data Shanghai Jiao Tong University tuberculosis:lung,bone,kidney,intestine,lymph node;tuberculous meningitis,.. One third of population infected (?)in the world, with 70%in Asia Two millions death each year Chinese patients,14.3%;Shanghai 5000/year;China >1.07 million/2009 World tuberculosis day:March 24,in memory of the day when Robert Koch discovered the bacillus in 1882.Nobel prize in 1905

Shanghai Jiao Tong University Tuberculosis-related data tuberculosis：lung, bone, kidney, intestine, lymph node; tuberculous meningitis, … One third of population infected (?) in the world, with 70% in Asia Two millions death each year Chinese patients, 14.3%; Shanghai 5000/year; China > 1.07 million/2009 World tuberculosis day：March 24, in memory of the day when Robert Koch discovered the bacillus in 1882. Nobel prize in 1905

上游充通大￥ Therapeutic history 后 Shanghai Jiao Tong University Before 1930's:I nutrition therapy:rest, nutrition,fresh air,cure rate 25% 1930~1950's:nutrition therapy physical therapy (artificial pneumothorax),cure rate 40% Drugs difficulty in entering the cells 1950's:streptomycin,isoniazid,rifampicin; cure rate >90% 21 century:multidrug resistance,TB incidence↑

Shanghai Jiao Tong University Therapeutic history Before 1930’s：nutrition therapy：rest, nutrition, fresh air, cure rate 25% 1930～1950’s： nutrition therapy + physical therapy (artificial pneumothorax) , cure rate 40% Drugs difficulty in entering the cells 1950’s：streptomycin, isoniazid, rifampicin； cure rate >90% 21 century：multidrug resistance, TB incidence ↑

上浒克通大睾 The evolu Shanghai Jiao Tong University The Nobel Prize in Physiology or Medicine 1952 "for his discovery of streptomycin,the first antibiotic effective The discovery of the against tuberculosis" antitubercular activity of aminoglycoside antibiotics streptomycin by Waksman et al in 1944 ushered in the modern era of tuberculosis treatment. Selman Abraham Waksman

Shanghai Jiao Tong University The discovery of the antitubercular activity of aminoglycoside antibiotics streptomycin by Waksman et al in 1944 ushered in the modern era of tuberculosis treatment. The evolution of antitubercular agents

上游充通大￥ Shanghai Jiao Tong University 1952,p-amino-salicylic acid(PAS) 1952,isoniazid Ethambutol 1959,rifampicin

Shanghai Jiao Tong University 1952, p-amino-salicylic acid(PAS) 1952, isoniazid Ethambutol 1959, rifampicin

上降文 Shangh 人/10万 20 结核 脑血管疾病 01 0 癌 10 心血管疾病 0 10 11D 1920 135 设0 1050 100 1970 1280 年 本世纪三大花因及结核的死亡率变化

Shanghai Jiao Tong University

上泽充通大睾 Anti-TB drugs 后 Shanghai Jiao Tong University First-line drugs: Isoniazid(异烟肼) Rifampicin(利福平) Ethambutol(乙胺丁醇) Pyrazinamide(吡嗪酰胺) Streptomycin(链霉素) Second-line drugs: Ethionamide(乙硫异烟胺) Para-aminosalicylic acid(对氨水杨酸) rifapentine(利福喷丁) sparfloxaxcin(司帕沙星)

Shanghai Jiao Tong University Anti-TB drugs First-line drugs: Isoniazid（异烟肼） Rifampicin（利福平） Ethambutol（乙胺丁醇） Pyrazinamide（吡嗪酰胺） Streptomycin（链霉素） Second-line drugs: Ethionamide（乙硫异烟胺） Para-aminosalicylic acid（对氨水杨酸） rifapentine（利福喷丁） sparfloxaxcin（司帕沙星）