上海交通大学：《药理学 Pharmacology》课程教学资源（讲义课件）抗菌药物概述人工合成药 Chemotherapy of microbial diseases

上通大学 Shanghai Jiao Tong Univer_. Chemotherapy of microbial diseases 殷明 2011.11

Chemotherapy of microbial diseases 殷明 2011.11

上商充通大￥ 一些事实数据 Shanghai Jiao Tong University 1940年前，小儿肺炎、痢疾、伤寒、斑疹伤 寒、鼠疫、霍乱、白喉、疟疾一不治之症 1930-1949上海传染病死亡率565/10万 1990 0.52/10万 1949年，中国人平均寿命 39岁 2004年，中国人平均寿命72岁（日本82岁)

Shanghai Jiao Tong University 1940年前，小儿肺炎、痢疾、伤寒、斑疹伤 寒、鼠疫、霍乱、白喉、疟疾——不治之症 1930-1949 上海传染病死亡率 565/10万 1990 0.52/10万 1949年，中国人平均寿命 39岁 2004年，中国人平均寿命72岁（日本82岁） 一些事实数据

上游充通大 Shanghai Jiao Tong University GENERAL PRINCIPLES OF ANTIMICROBIAL THERAPY

Shanghai Jiao Tong University GENERAL PRINCIPLES OF ANTIMICROBIAL THERAPY

上商充通大￥ Shanghai Jiao Tong University ©Introduction ©Mechanism of action Antibiotic Resistance General principles of clinical use

Shanghai Jiao Tong University Introduction Mechanism of action Antibiotic Resistance General principles of clinical use

上商充通大 Definition Shanghai Jiao Tong University In the strictest sense,antibiotics are antibacterial substances produced by various species of microorganisms (bacteria, fungi,and actinomycetes)that suppress the growth of other microorganisms. Common usage often extends the term antibiotics to include synthetic antimicrobial agents,such as sulfonamides and quinolones

Shanghai Jiao Tong University Definition In the strictest sense, antibiotics are antibacterial substances produced by various species of microorganisms (bacteria, fungi, and actinomycetes) that suppress the growth of other microorganisms. Common usage often extends the term antibiotics to include synthetic antimicrobial agents, such as sulfonamides and quinolones

上商充通大 classification Shanghai Jiao Tong University according to the actions against the type of organism Antibacterial Antiviral 圈Antifungal

Shanghai Jiao Tong University classification according to the actions against the type of organism Antibacterial Antiviral Antifungal

上游充通大学 The discovery of Penicillin 后 Shanghai Jiao Tong University 1928:Alexander Fleming discovered the first antibiotic. He observed that Penicillium fungus made an antibiotic, penicillin,that killed S.aureus. Two Oxford University specialists Dr Howard W Florey Penicillium and his German associate Dr colony Ernest Boris Chain spent month after month attempting to extract the essential substance from Fleming's mould. Bacteria inhibited @ On 12 February,1941,the first dose of isolated penicillin was injected into a human being Bacteria Nobel Prize for Medicine in 1945

Shanghai Jiao Tong University 1928: Alexander Fleming discovered the first antibiotic. He observed that Penicillium fungus made an antibiotic, penicillin, that killed S. aureus. Two Oxford University specialists Dr Howard W Florey and his German associate Dr Ernest Boris Chain spent month after month attempting to extract the essential substance from Fleming's mould. On 12 February, 1941, the first dose of isolated penicillin was injected into a human being Nobel Prize for Medicine in 1945 The discovery of Penicillin

后 The Nobel Prize in Physiology or Medicine 1945 "for the discovery of penicillin and its curative effect in various infectious diseases" Sir Alexander Ernst Boris Chain Sir Howard Walter Fleming Florey

Shanghai Jiao Tong University

上商充通大 Antibiotics Shanghai Jiao Tong University >Most significant discovery of modern medicine Save millions of lives

Shanghai Jiao Tong University Antibiotics Ø Most significant discovery of modern medicine Ø Save millions of lives

上商充通大 Shanghai Jiao Tong University Academic terms Antimicrobial spectrum Bactericidal-MBC,bacteriostatic-MIC Therapeutic index:LDsO/ED50 Post antibiotic effect

Shanghai Jiao Tong University Academic terms Antimicrobial spectrum Bactericidal-MBC, bacteriostatic-MIC Therapeutic index: LD50 /ED50 Post antibiotic effect