复旦大学：《生理学》课程教学资源（PPT课件）BASIC FUNCTIONS OF THE CELL

Chapter 2 BASIC FUNCTIONS OF THE CELL 1.The cell membrane its transport ·Fluid mosaic model Transport across cell membrane Simple diffusion Facilitated diffusion Active transport Secondary active transport Exocytosis endocytosis

Chapter 2 § 1. The cell membrane & its transport • Fluid mosaic model • Transport across cell membrane * Simple diffusion * Facilitated diffusion * Active transport * Secondary active transport * Exocytosis & endocytosis BASIC FUNCTIONS OF THE CELL

脂质双分子层 膜外侧糖链 亲水性基团 蛋白质 疏水性基团 Fluid mosaic model of membrane

Fluid mosaic model of membrane

Simple diffusion its energy source O2,CO2,NH3,NO,etc. Facilitated diffusion its characteristics Facilitated diffusion via ion channel Chemically gated channel Voltage-gated channel Mechanically gated channel Nat,K+,Ca2+,Cl-channel Facilitated diffusion via carrier Glucose,amino acids,some ions,etc

* Simple diffusion & its energy source O2 , CO2 , NH3 , NO, etc. * Facilitated diffusion & its characteristics Facilitated diffusion via ion channel Chemically gated channel Voltage-gated channel Mechanically gated channel Na+ , K+ , Ca2+, Cl− channel Facilitated diffusion via carrier Glucose, amino acids, some ions, etc

0.。 00 通道开放 Facilitated diffusion via ion channel

Facilitated diffusion via ion channel

Facilitated diffusion via carrier

Facilitated diffusion via carrier

Active transport Sodium-potassium pump its effects Other pumps:calcium pump,proton pump Secondary active transport Membrane protein:pump+transporter Forms:symport antiport Exocytosis endocytosis Exocytosis:cell secretion Endocytosis:phagocytosis Receptor mediated endocytosis

* Active transport Sodium-potassium pump & its effects Other pumps: calcium pump, proton pump * Secondary active transport Membrane protein: pump+transporter Forms: symport & antiport * Exocytosis & endocytosis Exocytosis: cell secretion Endocytosis: phagocytosis Receptor mediated endocytosis

3 Na+ 膜外 2K ATP酶 膜内 3 Na+ 2K+ ATP ADP+Pi Sodium-potassium pump

Sodium-potassium pump

Na+ 葡萄糖 氨基酸 紧密连接 mnnKm 钠泵 钠泵 Na t 载体 载体 葡萄糖 氨基酸 Secondary active transport

Secondary active transport

线粒体 粗面内质网 吞噬体溶酶体 高尔基复合体 0 @ 吞噬体 溶酶体 Exocytosis endocytosis

Exocytosis & endocytosis

再循环囊泡 ④ 吞饮小泡 胞内体 Receptor mediated 次级溶酶体 endocytosis

Receptor mediated endocytosis