免疫系统遗传学（PPT讲稿）Genetics of the Immune system

Genetics of the Immune system Immune system-protects us against foreign material proteins, viruses, bacterial infections Immune system has two major divisions Non-Specific response block entry of foreign agents into the body block the spread of foreign agents if they get into the body Specific responses antibody-mediated immunity -humoral response cell-mediated immunity -cellular response

Genetics of the Immune system Immune system - protects us against foreign material proteins, viruses, bacterial infections Immune system has two major divisions. Non-Specific Response - block entry of foreign agents into the body - block the spread of foreign agents if they get into the body Specific Responses - antibody-mediated immunity - humoral response - cell-mediated immunity – cellular response

Foreign versus self To protect the body from harmful organisms, the immune system identifies foreign molecules as nonself and destroys those cells Molecules recognized by the immune system are called antigens Antigens are usually protein fragments or carbohydrates during development, the immune system removes components that recognize“ self Immune response to one's own body is called autoimmunity

Foreign versus Self To protect the body from harmful organisms, the immune system identifies foreign molecules as “nonself” and destroys those cells. Molecules recognized by the immune system are called antigens. Antigens are usually protein fragments or carbohydrates. During development, the immune system removes components that recognize “self”. Immune response to one’s own body is called autoimmunity

1. Physical barriers kin, mucous membranes and their secretions infection fighting chemicals, in tears saliva. other body fluids 2. Nonspecific- Innate defenses phagocytosis-(engulfing cells) inflammatory response ver antI-microbial proteins complement, collectins, cytokines 3. Specific response Acquired Immunity Humoral immune response B cells, antibodies, memory cells Cellular immune response T cells, cytokines, memory cells

1. Physical barriers - skin, mucous membranes and their secretions - infection fighting chemicals,in tears, saliva, other body fluids 2. Nonspecific - Innate defenses - phagocytosis - (engulfing cells) - inflammatory response - fever - anti-microbial proteins complement, collectins, cytokines 3. Specific response - Acquired Immunity - Humoral immune response - B cells, antibodies, memory cells - Cellular immune response - T cells, cytokines, memory cells

Bacteria Viruses Innate response Physical Cytokines Cilia barriers Antimicrobial secretions Mucous membranes Macrophages Acquired response Macrophages Cellular response present antigens Humoral response T cells Cytokines B cells Memory B cells Cytotoxic T cells Plasma cells Antibodies

Bacteria Viruses Acquired response Mucous membranes Physical barriers Cilia Innate response Cytokines Antimicrobial secretions Macrophages Macrophages present antigens Cellular response T cells Cytokines Cytotoxic T cells Humoral response B cells Memory B cells Plasma cells Antibodies

Inflammatory response A non-specific response triggered by penetration of bacteria -skin, respiratory, digestive, urinary or reproductive tract Two main players histamine complement

Inflammatory response A non-specific response triggered by - injury - penetration of bacteria -skin, respiratory, digestive, urinary or reproductive tract Two main players - histamine - complement

Histamine dilates local blood vessels increases capillary permeability Result is redneSs, heat and swelling heat -unfavorable to microorganisms mobilizes white blood cells(monocytes) raises metabolic rate of surrounding cells Complement- chemotaxis agent recruits in wbc to injury site The Inflammatory response starts with release of histamine and other chemicals ends with WbC cleaning up the debris

Histamine - dilates local blood vessels - increases capillary permeability Result is redness, heat and swelling heat - unfavorable to microorganisms - mobilizes white blood cells (monocytes) - raises metabolic rate of surrounding cells Complement - chemotaxsis agent - recruits in WBC to injury site The Inflammatory Response - starts with release of histamine and other chemicals - ends with WBC cleaning up the debris

Tissue injury Release of histamine complement, and other chemicals Histamine Histamine Complement Local dilation of Increased local Chemotactic attraction blood vessels capillary permeability of phagocytes to injured area Accumulation of fluid Increased blood delivery to injured area (which includes antibodies omplement, clotting proteins, and phagocytes)in tissue spaces Redness一 Swelling s 相e ain Healing

Complement system chemical defense system that kills microorganisms named the complement system because of the way it works together with the immune system are a series of proteins, cl, C2, etc C5-C9-form a large multi-protein complex MAC-membrane-attack complex MAC-inserts itself into the membrane of invading microorganisms creates a pore disrupts control of ion balance cells burst

Complement System - chemical defense system that kills microorganisms - named the complement system because of the way it works together with the immune system - are a series of proteins, C1, C2 , etc - C5-C9 - form a large multi-protein complex - MAC - membrane-attack complex MAC - inserts itself into the membrane of invading microorganisms - creates a pore - disrupts control of ion balance - cells burst

Complement Bacteria Phagocyte Bacteria ① Ruptures② Establishes③ Coating of (lyses) chemical bacterial cells bacterial cells gradient for enhances attraction of recognition phagocytes and engulfing y phagocytes

Anti-microbial chemicals on the non-specific response collectins recognize the sugar moieties present on the surface of foreign cells cytokines interferons(chemical scouts), alert other cells to the presence of invaders also anti-viral interleukins(fever high temp-kills some infecting bacteria lowers blood iron levels tumor necrosis factor

Anti-microbial chemicals on the non-specific response - collectins - recognize the sugar moieties present on the surface of foreign cells - cytokines - interferons (chemical scouts), alert other cells to the presence of invaders - also anti-viral - interleukins (fever) - high temp - kills some infecting bacteria - lowers blood iron levels - tumor necrosis factor