南方医科大学：《内科学》课程教学课件（讲稿）第二篇 呼吸系统疾病 第三章 慢性支气管炎——慢性阻塞性肺疾病 Chronic Obstructive Pulmonary Disease（英文版）

LOBAL INITIATIVEA FOR CHRONIC OBSTRUCTIVE LUNG DISEASESMA Chronic obstructive Pulmonary Disease Chen xin M.D.,Pulmonary Medicine 0n1c0 zhujiang hospital,southern LUNG medical university GoLD

Chronic Obstructive Pulmonary Disease Chen xin M.D., Pulmonary Medicine zhujiang hospital, southern medical university

、TA三E) VIC OBSTRUCTIVE JING DISEASSS Introduction Chronic Obstructive Pulmonary Disease(COPD) .the 4th leading cause of death globally is projected to be the 3rd leading cause of death by 2020

Introduction Chronic Obstructive Pulmonary Disease (COPD) •the 4th leading cause of death globally •is projected to be the 3rd leading cause of death by 2020

于O3△&TA夏VB2 FOR Definition(2020) ANIC OBSTRUCTIVE LUNG DISED Chronic Obstructive Pulmonary Disease(COPD)is a common,preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases and influenced by host factors including abnormal lung development.Significant comorbidities may have an impact on morbidity and mortality

Definition(2020) • Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases and influenced by host factors including abnormal lung development. Significant comorbidities may have an impact on morbidity and mortality

GLOBAL INITIATIVE FOR VIC OBSTRUCIVE LUNG DISEASW Definition COPD is a preventable and treatable disease with some significant extrapulmonary effects. Characterized by airflow limitation that is not fully reversible

Definition • COPD is a preventable and treatable disease with some significant extrapulmonary effects. • Characterized by airflow limitation that is not fully reversible

LOBAL INITIATIVE FOR Definition VCOBSTRUCTIVE LUNG DISY The airflow limitation is usually progressive and associated with the chronic inflammatory response of the lung to noxious particles or gases. Acute exacerbations and other complications influence the severity of the disease

Definition • The airflow limitation is usually progressive and associated with the chronic inflammatory response of the lung to noxious particles or gases. • Acute exacerbations and other complications influence the severity of the disease

/GIOB△L INITIATIVE FOR VIC OBSTRUCTIVE JING DISEASWS Burden of COPD a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing. COPD prevalence,morbidity,and mortality vary across countries and across different groups within countries

Burden of COPD • a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing. • COPD prevalence, morbidity, and mortality vary across countries and across different groups within countries

CIOB△INITIATIVE FOR CRONIC OBSTRUCTIVE LUNG DISEASSNA Burden of COPD The burden of COPD is projected to increase in the coming decades due to continued exposure to COPD risk factors and the changing age structure of the world's population

Burden of COPD • The burden of COPD is projected to increase in the coming decades due to continued exposure to COPD risk factors and the changing age structure of the world’s population

11T△夏VE● Percent Change in Age-Adjusted TRUCTIVEI Death Rates,U.S.,1965-1998 Proportion of 1965 Rate 3.0 Coronary Stroke Other CVD COPD All Other 25 Heart Causes Disease 2.0 1.5 1.0 0.5 -59% -64% -35% +163% -7%

Percent Change in Age-Adjusted Death Rates, U.S., 1965-1998 0 0.5 1.0 1.5 2.0 2.5 3.0 Proportion of 1965 Rate 0.0 0.5 1.0 1.5 2.0 2.5 3.0 –59% –64% –35% +163% –7% Coronary Heart Disease Stroke Other CVD COPD All Other Causes

GLOBAL INITIATIVE FOR 550 CDTRUCTIVE LUNG DISESES 500 Heart disease 250 Cancer 150 Of the six 100 Stroke 50 000-0-000-0-0 leading causes 0 1970 1974 1978 19821986199019941998 2002 of death in the Year of Death United States, only COPD has Chronic Obstructive 50 Pulmonary Disease been increasing Accidents ● 0-0-00-00-000 steadily since 00-0-0-0000 1970 000 ●● Diabetes Melitus Source:Jemal A.et al.JAMA 2005 1970 19741978 198219861990 1994 1998 2002 Year of Death

Of the six leading causes of death in the United States, only COPD has been increasing steadily since 1970 Source: Jemal A. et al. JAMA 2005

全飞了三 Disease Trajectory of a 易 Patients with COPD Symptoms Exacerbations Exacerbations Deterioration Exacerbations End of Life

Disease Trajectory of a Patients with COPD Symptoms Exacerbations Exacerbations Exacerbations Deterioration End of Life