郑州大学：泌尿系统（PPT课件讲稿）Disorder of potassium metabolism

Disorder of potassium metabolism Zhao Mingyao BMC.ZZU

Zhao Mingyao BMC.ZZU. Disorder of potassium metabolism

Disorder of potassium metabolism 3.5~5.5 Normal level 5.5 Hyperkalemia

Disorder of potassium metabolism [K+ ]s mmol/L Status 3.5 ~ 5.5 Normal level 5.5 Hyperkalemia ?

Function ofk+ enzyme activity cellular electricity cellular osmolality acid-base balance K a

Function of K+ enzyme activity cellular electricity cellular osmolality acid-base balance K+ Na+ H+

Part 1 General introduction 1. Potassium content and distribution Source: fruit, vegetable, coffee

Part 1 General introduction 1.Potassium content and distribution Source: fruit, vegetable, coffee

50~55mmol/Kg×BW K+ K+ 3.5-5.5 mmol/L 140~160mmo/L ECF ICF 14 Potassium content and distribution

140~160mmol/L 3.5~ 5.5 mmol/L ECF ICF K+ K+ Potassium content and distribution 1.4% 90% 50~55mmol/Kg×BW

2 Maintenance oft balance OUTSIDE At rest Water channel Cell membrane embrane Em=-75 mv) OUTSID Immediately after INSIDE OUTSIDE NSIDE

2.Maintenance of K+ balance

intake ECE ICF K+ K+ 3.5~5.5mmoL pump channe 140~160mmoL kidney Gi tract Direction oft shifting 90% Skin? Maintenance oft balance

Direction of K+ shifting 140~160mmol/L 3.5~ 5.5 mmol/L ECF ICF K+ K+ Maintenance of K+ balance intake kidney GI tract 90% Skin? 10% channel pump

(1) The control of K transfer between intra- extracellular compartments The Na*/KATPase(membrane pump Permea bility of ion channels

(1) The control of K+ transfer between intra- & extracellular compartments • The Na+ /K+ATPase (membrane pump ) • Permeability of ion channels

ECF ICF K pump channel Insulin, B-adrenergic agonist, ADS, 「K+s」, exercise,pH, ECF oSmolality↑ K+ shifts between icf and ecF

ECF ICF K+ K+ shifts between ICF and ECF Insulin, β-adrenergic agonist, ADS, [K+ ]s↓, exercise, pH ↓, ECF osmolanity ↑ channel pump

(2) Regulation of renal K excretion

(2) Regulation of renal K+ excretion ?