扬州大学：《妇产科学》课程教学课件（PPT讲稿）39 多囊卵巢综合征 Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

IntroductionJten.Definition:力RDvary- polycysticsyndromeovary(PCos) is a generic descriptionfor a broad spectrum of clinicalUrethralopeningand morphological findings inVaginawithendocrineanwomendysfunction,specificallyabnormal androgennproductionDeaylaandmetabolism

Introduction • Definition: – polycystic ovary syndrome (PCOS) is a generic description for a broad spectrum of clinical and morphological findings in women with an endocrine dysfunction, specifically abnormal androgen production and metabolism

IntroductionUtenuPCoS was firstidentifiedbySteinOand Leventhal in 1935 so that itDvarycan also be knownSteinasLeventhal SyndromeUrethralopeningVaginaFaliepiartiteDearyia

Introduction • PCOS was first identified by Stein and Leventhal in 1935 so that it can also be known as Stein – Leventhal Syndrome

Etiology& PathopysiologyJtenWhat we think we know"Viciouscycle"DvaryAbnormalgonadotropinsecretionExcessLHandlow,tonicFSHUrethralopeningHypersecretionofandrogensVagina- Disrupts follicle maturationSubstrateforperipheralaromatizationFallopinDeayNegativefeedbackonpituitaryay-Decreased FSH secreationnInsulinresistance,Elevatedinsulinlevels

Etiology & Pathopysiology What we think we know. • “Vicious cycle” • Abnormal gonadotropin secretion – Excess LH and low, tonic FSH • Hypersecretion of androgens – Disrupts follicle maturation – Substrate for peripheral aromatization • Negative feedback on pituitary – Decreased FSH secreation • Insulin resistance, Elevated insulin levels

PathologyOvaries:enlarged and/orpolycysticovariesEndometrium: Lack of ovulation foran extended period of time maycause excessive thickening of theendometrium (the lining of theuterus)

Pathology • Ovaries: enlarged and/or polycystic ovaries • Endometrium: Lack of ovulation for an extended period of time may cause excessive thickening of the endometrium (the lining of the uterus)

PathologyD1=3.30cmD2=2:37cmCircum=8.96cmArea=6.14cm?

Pathology

What Are the Symptoms of PCoS?Irregular or Lack ofMenses:Women will have "spotty"periods(1every couple of months).Also,in some women with Pcos theysimply cease having a menses atall.2

What Are the Symptoms of PCOS? • Irregular or Lack of Menses: • Women will have “spotty” periods (1 every couple of months). Also, in some women with PCOS they simply cease having a menses at all

SymptomsHirsutism:-Excessive body hair. In women withPcos dark, coarse hair will appear onthe face, neck, chest, arms, and inbetweenthelegs.ChinHair

Symptoms • Hirsutism : – Excessive body hair. In women with PCOS dark, coarse hair will appear on the face, neck, chest, arms, and in between the legs

SymptomsWeightProblems-Dependingonthewoman,therecouldbeadecreaseof weightora rapidfluctuationofweight thatsettlesaroundthestomachthatwillleadtomorbidobesity.图OO00OFO108209090?Ova

Symptoms • Weight Problems : – Depending on the woman, there could be a decrease of weight or a rapid fluctuation of weight that settles around the stomach that will lead to morbid obesity

SymptomsAcne:with PcoS-Becausearewomenproducing more male hormone, thatproduces more sebum (skin oils andoldtissue)andcausesblockedporesand more acne around the jawline,armsandchest

Symptoms • Acne : – Because women with PCOS are producing more male hormone, that produces more sebum (skin oils and old tissue) and causes blocked pores and more acne around the jawline, arms and chest