复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）T cell & T cell-mediated immunity

T celll T cell-mediated immunity Rui He ruihe@fudan.edu.cn Department of Immunology Shanghai Medical School Fudan University

T cell & Rui He ruihe@fudan.edu.cn Department of Immunology Shanghai Medical School Fudan University T cell-mediated immunity

Microbe Innate immunity Adaptive immunity I B lymphocytes Epithelial 薄 Antibodies barriers 真 ③ Phagocytes T lymphocytes Effector T cells 参 Complement NK cells Hours Days 6 Time after infection Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition. opyright 2009 by Saunders, an imprint of Elsevier, Inc. All rights reserved

Types of adaptive immune responses Humoral Cell-mediated mmunity 督 督 Intracellular Extracellular Phagocytosed ymphocyt Helper B lymphocyte T lymphocyte T lymph Secreted antibody Effecto 督 x Transferred by」ar Serum Cells Cells es)(T lymphocytes),(T lymphocytes) Block Activate Kill infected infections and macrophages cells and Functions to kill eliminate extracellular phagocytosed:reservoirs microbes microbes of infection Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition Copyright 2009 by Saunders, an imprint of Elsevier, Inc, All rights reserved

Types of adaptive immune responses

Agenda a Types of cell-mediated immune reactions a the differentiation of cd4tth cell subsets Q Effector mechanisms of cell-mediated immunity

Agenda ❑ Types of cell-mediated immune reactions ❑ The differentiation of CD4+Th cell subsets ❑ Effector mechanisms of cell-mediated immunity

Types of cell-mediated immune reactions 口CD4+ Th responses 口CD8+ CTL responses Delayed-type Hypersensitivity (DTH) T cell-dependent immune reactions that cause normal tissues injury NK cell mediated innate immunity, kill infected cell early

Types of cell-mediated immune reactions ❑ CD4+ Th responses ❑ CD8+ CTL responses Delayed-type Hypersensitivity (DTH) T cell-dependent immune reactions that cause normal tissues injury NK cell mediated innate immunity, kill infected cell early

Different types of microbes elicit distinct protective T cell responses 日cD4+Th1 responses microbes residing within the phagosomes of phagocytes 日cD8+ CTL responses microbes residing in the cytoplasm of various cell types 日cD4+Th2 responses helminthic parasites Defects in CMI result in increased susceptibility to infection by viruses and intracellular bacteria

❑ CD4+ Th1 responses microbes residing within the phagosomes of phagocytes ❑ CD8+ CTL responses microbes residing in the cytoplasm of various cell types ❑ CD4+ Th2 responses helminthic parasites Different types of microbes elicit distinct protective T cell responses Defects in CMI result in increased susceptibility to infection by viruses and intracellular bacteria

B Phagocytes with ingested microbes; Infected cell with microbial antigens in vesicles microbes in cytoplasm CD4+ effector CD8+1 CD8+ T cells T cells (TH1 cells) (CTLS)I (CTLS) Cytokine secretion Macrophage Inflammation Killing of activation→ infected cel killing of ingested microbes Abbas et al: Cellular and Molecular Immunology, Updated 6th Edition. Copyright 2009 by Saunders, an imprint of Elsevier, Inc. All rights reserved

Cell-mediated immune responses a The development of effector T cells u migration of effector t cells and other leukocytes to sites of infection o Effector functions to eliminate microbes

Cell-mediated immune responses ❑ The development of effector T cells ❑ Migration of effector T cells and other leukocytes to sites of infection ❑ Effector functions to eliminate microbes

The differentiation of cD4+Th cell subsets

The differentiation of CD4+Th cell subsets

The subsets of cD4+Th cells Pathogen ⊙→m一一如m -◎◎⑥-一=一 Humoral immunity and allergy Naive L-6T2 CD4. T cell T cell TGFB IL-17 T◎→→ Tissue inflammation IFNY T77 cell l-23 Nature Reviews Immunology How they are induced, What cytokines they produce What effector mechanisms they activate

The subsets of CD4+Th cells ▪ How they are induced, ▪ What cytokines they produce ▪ What effector mechanisms they activate