复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）Immunity to tumors

Medical Immunology Department of Immunology NIV Yiwei chu

Medical Immunology Department of Immunology Yiwei Chu

Chapter 17 Immunity to tumors June,21,2010

DEPARTMENT OF IMMUNOLOGY Chapter 17 Immunity to tumors June, 21, 2010

Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy

DEPARTMENT OF IMMUNOLOGY Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy

Cancer is a major health problem worldwide and one of the most important causes of morbidity and mortality in children and adults

DEPARTMENT OF IMMUNOLOGY Cancer is a major health problem worldwide and one of the most important causes of morbidity and mortality in children and adults

Robin bush The sister of George W. Bush die from leukemia at the age of 4 Walt Disney This famous animator, producer and co-founder of the corporation known as The Walt Disney Company died at the age of 65 from lung cancer, making him one of the most famous celebrities to have died from smoking Paul newman Paul Newman was of course a great actor, but was known well for his healthy line of food He struggled with lung cancer, and passed away on September 26, 2008, at the age of 83

DEPARTMENT OF IMMUNOLOGY Robin Bush The sister of George W. Bush, die from leukemia, at the age of 4. Walt Disney This famous animator, producer and co-founder of the corporation known as The Walt Disney Company died at the age of 65 from lung cancer, making him one of the most famous celebrities to have died from smoking. Paul Newman Paul Newman was of course a great actor, but was known well for his healthy line of food. He struggled with lung cancer, and passed away on September 26, 2008,at the age of 83

General Features Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host Immune responses frequently fail to prevent the growth of tumors . The immune system can be activated external stimuli to effectively kill tumor cells and eradicate tumors

DEPARTMENT OF IMMUNOLOGY General Features ❖ Tumor express antigens that are recognized as foreign by the immune system of the tumor-bearing host. ❖ Immune responses frequently fail to prevent the growth of tumors. ❖ The immune system can be activated external stimuli to effectively kill tumor cells and eradicate tumors

Tumor Antigen Mouse with chemical carcinogen induced tumor Resect tumor Isolate CD8+ T cells Transplant tumor cells Transplant tumor cells Adoptively transfer into original Tumor into syngeneic mouse T cells into recipient tumor-bearing mouse cells of tumor transplant Eradication No tumor growth Tumor growth of tumor

DEPARTMENT OF IMMUNOLOGY Tumor Antigen

Immune responses frequently fail to prevent the growth of tumors s First, tumor cells are derived from host cells Second, the rapid growth and spread of tumors Third, specialized mechanisms for evading host Immune responses

DEPARTMENT OF IMMUNOLOGY ❖ Immune responses frequently fail to prevent the growth of tumors ❖ First, tumor cells are derived from host cells. ❖ Second, the rapid growth and spread of tumors ❖ Third, specialized mechanisms for evading host immune responses

Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy

DEPARTMENT OF IMMUNOLOGY Content 1. General Features 2. Tumor antigen 3. Immune Responses 4. Evasion of Immune Responses 5. Immunotherapy

Tumor Antigen The earliest classification . Tumor-specific antigen Tumor-associated antigen

DEPARTMENT OF IMMUNOLOGY Tumor Antigen The earliest classification: ❖ Tumor-specific antigen ❖ Tumor-associated antigen