复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）Antigen Presenting Cell and Antigen Presentation

明正 道谊 Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY

Antigen Presenting Cell and Antigen Presentation Haifeng Gao hfgao@fudan.edu.cn DEPARTMENT OF IMMUNOLOGY

4 Antigen Presenting Cells ◆ Antigen Processing Antigen Presentation

Antigen Presenting Cells Antigen Processing Antigen Presentation

First line of defense Innate Immunit Native N on-specifIc No memory to antigens A cquired Adaptive Immunity Specific Memory to antigens Recognition by receptor

First line of defense Native Non-specific No memory to antigens Acquired Specific Memory to antigens Recognition by receptor Innate Immunity Adaptive Immunity

Antigen Presenting Cell, APC Antigen fragment SMHC TCR\ Pathogens APC T Cell

Antigen Presenting Cell, APC APC Antigen fragment MHC TCR Pathogens T Cell

CONCEPT APCs are immunocytes that can uptake, process and present antigens to other lymphocytes

APCs are immunocytes that can uptake, process and present antigens to other lymphocytes. CONCEPT

Toy- body T-cell T-cell epitope CD4 T APC

Can all APCs stimulate T cells to proliferate?

Can all APCs stimulate T cells to proliferate?

CLASIFICATION Dendritic cell Macrophage B lymphocyte a。分 备B8 Figure 1-22 part 1 of 3 Immunobiology, 6/e. (e Garland Science 2005) Professional APC: constitutively express MHc II molecules MHCI

Professional APC: constitutively express MHC II molecules CLASIFICATION MHC I

Professional APCs Dendritic Cells (DCs) Macrophages(Md) B Lymphocytes

Dendritic Cells (DCs) Macrophages (M) B Lymphocytes Professional APCs

Non-professional APCs E ndothelial cells Epithelial Cells Fibroblast cells Non-professional APC: express MHCI molecules

Endothelial Cells Epithelial Cells Fibroblast Cells …… Non-professional APCs Non-professional APC: express MHC I molecules