复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）review

Medical Immunology Department of Immunology Yiwei Chu 储以微 yichu@shmu.edu.cn 2010-7-7

Medical Immunology Department of Immunology Yiwei Chu 储以微 ywchu@shmu.edu.cn 2010-7-7

Define of immunology IMMUNITY protection from disease(infectious disease) IMMUNE SYSTEM organ, cel, molecule and gene IMMUNE RESPNSE response to the foreign substances

IMMUNITY ---protection from disease (infectious disease) IMMUNE SYSTEM --- organ, cell, molecule and gene IMMUNE RESPNSE --- response to the foreign substances Define of Immunology

Define of immunology IMMUNE FUNCTIONS immune defence(infectious disease) immune surveillance immune homeostasis

IMMUNE FUNCTIONS ---immune defence (infectious disease) --- immune surveillance --- immune homeostasis Define of Immunology

Define of immunology IMMUNITY protection from disease(infectious disease) IMMUNE SYSTEM organ, cel, molecule and gene IMMUNE RESPNSE response to the foreign substances

IMMUNITY ---protection from disease (infectious disease) IMMUNE SYSTEM --- organ, cell, molecule and gene IMMUNE RESPNSE --- response to the foreign substances Define of Immunology

Innate and Adaptive Immunity Innate Adaptive Characteristics Specificity For structures shared by For antigens of microbes and groups of related microbes for nonmicrobial antigens Diversity Limited: germline-encoded Very large: receptors are produced y somatic recombination of gene segments Memory None Yes Nonreactivity to selfYes Yes Components Physical and Skin, mucosal epithelia Lymphocytes in epithelia chemical barriers antimicrobial chemicals antibodies secreted at epithelial surfaces Blood proteins Complement Antibodies Cells Phagocytes(macrophages. Lymphocytes neutrophils), natural killer cells

Innate and Adaptive Immunity

Adaptive Immune Responses Feature I Functional significance Specificity E sures that distinct antigens elicit specific responses Diversity Enables immune system to respond to a large variety of antigens Memory Leads to enhanced responses to repeated exposures to the same antigens Specialization Generates responses that are optimal for defense against different types of microbes Self-limitation Allows immune system to respond to newly encountered antigens Nonreactivity Prevents injury to the host during to self responses to foreign antigens

Adaptive Immune Responses

Adaptive Immune Responses Cellular Components Lymphocytes B, Th CTL nKt Antigen-presenting cells(APCs) DC Mo, B Effector cells Activated T cells, mononuclear phagocytes

Cellular Components Adaptive Immune Responses • Lymphocytes - B, Th, CTL, NKT • Antigen-presenting cells(APCs) - DC, Mj, B • Effector cells - Activated T cells, mononuclear phagocytes

Basic Immunology Recognition Activation Effection Ag(antigen) double recognition humural immunity APC double signaling cellular immunity (antigen presenting cell)

Basic Immunology Recognition Activation Effection Ag (antigen) double recognition humural immunity APC double signaling cellular immunity (antigen presenting cell)

Chapter 1 efinition ofantigen Antigen(Ag) Substances that combine specifically with a B or T cell's antigen-binding receptors can then induce an immune response are called antigens

Antigen (Ag) Chapter 1 Definition of antigen Substances that combine specifically with a B or T cell’s antigen-binding receptors can then induce an immune response are called antigens

Chapter 2 Characteristics ofantigen The antigen molecule generally pose two natures, that is (1) immunogenicity (2) antigenicity

Chapter 2 Characteristics of antigen （1）immunogenicity （2）antigenicity The antigen molecule generally pose two natures, that is