复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）Antigens（Ag）

e DEPARTMENT OF IMMUNOBIOLOGY Antigens(Ag) Xiaowu hong xiaowuhong@fudna.edu.cn 021-54237093 Department of Immunology Shanghai medical college of Fudan University

DEPARTMENT OF IMMUNOBIOLOGY Antigens (Ag) Xiaowu Hong xiaowuhong@fudna.edu.cn 021-54237093 Department of Immunology Shanghai Medical College of Fudan University

antigen I Definition and characteristics of antigen I Properties ofAg: Foreignness and specificity Il Factors that influence immunogenicity IV Classification of antigen V Nonspecific stimuli for immune response

I Definition and characteristics of antigen II Properties of Ag: Foreignness and specificity III Factors that influence immunogenicity IV Classification of antigen V Nonspecific stimuli for immune response antigen

Chapter 1 efinition ofantigen Antigen(Ag) Substances that combine specifically with a B or T cell's antigen-binding receptors can then induce an immune response are called antigens

Antigen (Ag) Chapter 1 Definition of antigen Substances that combine specifically with a B or T cell’s antigen-binding receptors can then induce an immune response are called antigens

Antigen(Ag Antigen binding triggers release of antibodies Antigen binding causes cytotoxic T cells Activated B ce Memory Activated Memory T cell cytotoxic T cell Antibodies B cel

Antigen (Ag) Antigen binding causes cytotoxic T cells Memory T cell Activated cytotoxic T cell Antigen binding triggers release of antibodies Memory B cell Activated B cell Antibodies

Chapter 2 Characteristics ofantigen The antigen molecule generally pose two natures, that is (1) immunogenicity (2) antigenicity

Chapter 2 Characteristics of antigen （1）immunogenicity （2）antigenicity The antigen molecule generally pose two natures, that is

(1)Immunogenicity Immunogenicity is the ability to induce a humoral and or cell mediated immune response, including Activated b cell induce production 人 of antibody and effector Activated Ctl lymphocytes antibody

(1) Immunogenicity Immunogenicity is the ability to induce a humoral and / or cell mediated immune response, including induce production of antibody and effector lymphocytes. Activated B cell antibody Activated CTL

(2) antigenicity Antigenicity is the ability to combine specifically with the final products of the above responses(i.e anti body and or cell-surface receptors)

(2) antigenicity Antigenicity is the ability to combine specifically with the final products of the above responses (i.e., antibody and /or cell-surface receptors)

antigenicity T T Ag i mmuogen icity

antigenicity immuogenicity T T T Ag

Specificity Specificity of antigen The characteristic that antigen only binds the antibody and sensitized lymphocyte specifically, is called specificity of antigen Specificity

1 Specificity Specificity of antigen The characteristic that antigen only binds the antibody and sensitized lymphocyte specifically, is called specificity of antigen（ Specificity ）

(1)Antigenic determinants or epitopes Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR)or to secreted antibodies

Antigenic determinants or epitopes are the immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes (TCR/BCR) or to secreted antibodies. (1) Antigenic determinants or epitopes