复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）AUTOIMMUNITY AND AUTOIMMUNE DISEASE

AUTOIMMUNITY AND ATONMMUNE DTSEASE Bo Gao, Ph. D. email: gb1112@163.com Tel:54237379 DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 1

1 Bo Gao, Ph.D. DEPARTMENT OF IMMUNOLOGY INSTITUTE FOR IMMUNOBIOLOGY 2010-07-02 Email: gb1112@163.com Tel: 54237379

Contents: g Introduction c Organ-Specific Autoimmune Diseases e Systemic Autoimmune Diseases Mechanisms of induction g Treatment

2 Contents: Introduction Organ-Specific Autoimmune Diseases Systemic Autoimmune Diseases Mechanisms of Induction Treatment

ntroduction

3 Introduction

Autoimmunity origins y Horror autotoxicus Literally the horror of self- toxicity a term coined by the German immunologist paul Ehrlich(1854-1915) to describe the body's innate aversion to immunological self-destruction Paul Ehrlich. Nobel Prize in 1908 for demonstrating production of anti body

4 Autoimmunity Origins ➢Horror autotoxicus: Literally, the horror of self￾toxicity. A term coined by the German immunologist Paul Ehrlich (1854-1915) to describe the body's innate aversion to immunological self-destruction. Paul Ehrlich , Nobel Prize in 1908 for demonstrating production of antibody

Clone selection hypothesis >Self-reactive lymphocyte were deleted during development Frank Burnet 1900--1990 E Nobel Prize 1960

5 Frank Burnet 1900--1990 Nobel Prize 1960 Clone selection hypothesis ➢Self-reactive lymphocyte were deleted during development

Definition of autoimmune disease Disease caused by failure of self-tolerance and subsequent Immune responses against self antigens are called autoimmune diseases

6 Definition of autoimmune disease ➢Disease caused by failure of self-tolerance and subsequent immune responses against self antigens are called autoimmune diseases

>5 to 7 adult affected >Two third women More than 40 human diseases autoimmune in origin

7 ➢5 % to 7% adult affected. ➢Two third women. ➢ More than 40 human diseases autoimmune in origin

Two types of autoimmune disease organ-specific non-organ-specific brain multiple sclerosis(?) thyroid Hashimoto·s thyroiditis primary myxoedema thyrotoxicosis muscle dermatomyositis stomach pernicious anaemia kidney SLE adrenal Addison's disease skin scleroderma pancreas SLE insulin-dependent diabetes mellitus Joints rheumatoid arthritis

8

Organ-Specific Autoimmune Diseases >Insulin-dependent diabetes mellitus > Multiple sclerosis >Myasthenia gravis >Graves's disease >Hashimoto disease > Goodpasture's syndrome

9 ➢Insulin-dependent diabetes mellitus ➢Multiple sclerosis ➢Graves’s disease ➢Myasthenia gravis ➢Hashimoto’ disease ➢Goodpasture’s syndrome …… Organ-Specific Autoimmune Diseases

Systemic autoimmune Diseases

10 Systemic Autoimmune Diseases