复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）B cell and B cell-mediated humoral immune response（1/2）

详 INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Department of Immunology Fudan University Wei xu. ph. D 021-54237749 wX2362@hotmail.com

INSTITUTE FOR IMMUNOBIOLOGY B cell and B cell-mediated humoral immune response Department of Immunology Fudan University Wei Xu, Ph.D 021-54237749 wx2362@hotmail.com

Adaptive immune response to pathogens Pathogens Humoral immunity cs Mature Secretes Bacteria Binds B cell Plasma cell viruses Fungi Cellular immunit Matures into active Foreign killer t cel proteins T cell CTL Virus-infected cell Killing reaction C ↓↓↓ Lymphokines Lysis

Adaptive immune response to pathogens

Overview of the humoral immune response against bacterial Humoral response CD4+Th Antigen B cell B cells interact with antigen Ab-secreti ng Antibody binds antigen and differentiate into plasma cells and facilitates its clearance antibody-secreting plasma cells from the body B cells plasma cells

Overview of the humoral immune response against bacterial B cells plasma cells

B lymphocyte 6 5%15%of peripheral lymphocytes g 25% lymph node and 45% splenic lymphocytes secret antibodies (ab) g act as antigen-presenting cell (APC)

B lymphocyte 5％～15％ of peripheral lymphocytes 25% lymph node and 45% splenic lymphocytes secret antibodies (Ab) act as antigen-presenting cell (APC)

B cells and humoral immune response 1. Surface molecules of b cell 2. B cell subsets 3.Bcel‖ development 4. Function and significance

B cells and humoral immune response 1. Surface molecules of B cell 2. B cell subsets 3. B cell development 4. Function and significance

1. Surface molecules of b cell Surface receptor 1)B cell antigen receotor(BCR) 2) BCR coreceptor 3 Cytokine receptor(CKR) Surface functional molecules

Surface receptor 1) B cell antigen receotor (BCR) 2) BCR coreceptor 3) Cytokine receptor（CKR） 1. Surface molecules of B cell Surface functional molecules

Surface receptor 1)B cell antigen receotor(BCR) BCR/mlgM 了 Membrane Ig(mlg) Mature B cell: mlgM mlgD BCR-Iga/gβ complex

Membrane Ig (mIg) Mature B cell： mIgM ＋ mIgD BCR-Igα/Igβ complex BCR/mIgM Surface receptor 1) B cell antigen receotor (BCR)

BCR-Iga/gβ complex BCR Iga Igβ galgβ

BCR-Iga/Igb complex

2. BCR coreceptor Help and strengthen the BCR-Ag-signaling CD19 B-specific surface marker sIgnal transduction CD21 CR2, receptor for C3d-bound Ag CD81 BCR-coreceptor ligation induce reversible palmitoylation of CD8 1 to stabilize the cd 9/ C D2 1/CD81 complex JBC2004;279:31973

2. BCR coreceptor CD19 B-specific surface marker signal transduction CD21 CR2，receptor for C3d-bound Ag CD81 BCR－coreceptor ligation induce reversible palmitoylation of CD81 to stabilize the CD19/CD21/CD81 complex Help and strengthen the BCR-Ag-signaling JBC 2004;279:31973

Coreceptor of BCR CR2 CD19 CD81 ITAM

Coreceptor of BCR