复旦大学：《医学免疫学 Medical Immunology》课程教学资源（PPT课件讲稿，英文版）Major Histocompatibilty Complex, MHC

INSTITUTE FOR IMMUNOBIOLOGY Major Histocompatibility Complex MHC Department of Immunology Fudan University BO GAO. Ph D 021-54237154 gaobo@fudan.edu.cn

INSTITUTE FOR IMMUNOBIOLOGY Major Histocompatibility Complex MHC Department of Immunology Fudan University Bo GAO, Ph.D 021-54237154 gaobo@fudan.edu.cn

Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance

Major Histocompatibilty Complex, MHC 1. Discovery of MHC 2. MHC Genes 3. Binding of Peptides to MHC Molecules 4. MHC polymorphism 5. Function and significance

Autograft Isograft Within an < Identical Twins] indIidual Allograft Between speaes Xenograft Types of graft

Types of graft

MHC of mice 1940s Inbred mouse strains H-2d H-2b BALB/c C57BL/6 (George D Snell) Inbred mouse strains- all genes are identical

（George D. Snell) 1940s H-2 d H-2 b BALB/c C57BL/6 Inbred mouse strains MHC of mice Inbred mouse strains - all genes are identical

Genetic basis of transplant rejection Transplantation of skin between strains showed that rejection or acceptance was dependent upon the genetics of each strain ACCEPTED Skin from an inbred mouse grafted onto the same strain of mouse REJECTED Skin from an inbred mouse grafted onto a different strain of mouse

Skin from an inbred mouse grafted onto the same strain of mouse Skin from an inbred mouse grafted onto a different strain of mouse ACCEPTED REJECTED Genetic basis of transplant rejection Transplantation of skin between strains showed that rejection or acceptance was dependent upon the genetics of each strain

MHC of mice H-2( Histocompatibility-2 O a single genetic region is identified by Snell's group which is primarily responsible for rapid rejection of tissue grafts, and this region was called the major histocompatibility locus The particular locus encodes a blood group antigen called antigen Il, and therefore this region was named histocompatibility-2, or simply H-2

H-2 ( Histocompatibility-2) A single genetic region is identified by Snell's group, which is primarily responsible for rapid rejection of tissue grafts, and this region was called the major histocompatibility locus. The particular locus encodes a blood group antigen called antigen II, and therefore this region was named histocompatibility-2, or simply H-2. MHC of mice

MHC of human HLA ( Human leukocyte antigen) Discovered by searching for cell surface molecules in one individual that would be recognized as foreign by another individual O leukocyte because the antibodies tested by binding to the leukocytes of other individuals. and antigens because the molecules were recognized by Jean dausset antibodies

Jean Dausset HLA ( Human leukocyte antigen) Discovered by searching for cell surface molecules in one individual that would be recognized as foreign by another individual leukocyte because the antibodies were tested by binding to the leukocytes of other individuals, and antigens because the molecules were recognized by antibodies MHC of human

O HLa proteins and the mouse H-2 proteins had essentially identical structure Genes encoding hla are homologous to the H-2 genes O They are all called MHC genes

HLA proteins and the mouse H-2 proteins had essentially identical structure. Genes encoding HLA are homologous to the H-2 genes. They are all called MHC genes

Immune response genes O Inbred strains of guinea pigs and mice differed in their ability to make antibodies against some simple synthetic polypeptides Responsiveness was inherited as a dominant mendelian trait O The relevant genes were called immune (Baruj Benacerraf) response (r genes, and they were all found to map to the mhc

(Baruj Benacerraf ) Inbred strains of guinea pigs and mice differed in their ability to make antibodies against some simple synthetic polypeptides Responsiveness was inherited as a dominant mendelian trait The relevant genes were called immune response (Ir) genes, and they were all found to map to the MHC Immune Response Genes

Immune Response genes O These immune response(Ir)genes, are in fact, MHC genes that encode MHC molecules that differ in their ability to bind and display peptides derived from various protein antigens

These immune response (Ir) genes, are, in fact, MHC genes that encode MHC molecules that differ in their ability to bind and display peptides derived from various protein antigens. Immune Response Genes