浙江大学医学院：《免疫学 Immunology》课程教学资源（PPT课件）Introduction、Brief History

Immunology Jianzhong Chen, PhD Institute of Immunology Zhejiang University

Immunology Jianzhong Chen, PhD Institute of Immunology Zhejiang University

References ◇何维主编。《医学免疫学》第二版,人民卫生出 版社2010 金伯泉主编。《医学免疫学》第五版人民卫生出 版社2008 o Abbus K, et al. Cellular and Molecular Immunology 7th edition. elsevier saunders. 2012 o Janeway CA, et al. Immunobiology. 8th ed. Garland Science Publishing. 2012

References  何维 主编。《医学免疫学》第二版 ，人民卫生出 版社 2010  金伯泉 主编。《医学免疫学》第五版 人民卫生出 版社 2008  Abbus A K, et al. Cellular and Molecular Immunology. 7th Edition,Elsevier Saunders . 2012  Janeway C A, et al. Immunobiology. 8th ed. Garland Science Publishing . 2012

Content o Introduction of Immunology o Brief History of Immunology

Content  Introduction of Immunology  Brief History of Immunology

Introduction of Immunology

Introduction of Immunology

ntroduction of Immunology Concept of immuni o Immune response o Immune cells o Tissues and Organs of the immune system ● Immunopathology

Introduction of Immunology  Concept of Immunity  Immune Response  Immune Cells  Tissues and Organs of the Immune System  Immunopathology

Immunity 1. Immunity: meaning the state of protection from infectious disease In 430BC, a plaque in athens Those who recovered from the plaque would not contact the disease a second time 2. Agents: microorganisms(viruses, bacteria etc and their products foods, chemicals, pollen, tumor cells, etc 3. Immune system: immune tissues and organs, immune cells immune molecules 4.Immune response: collective and coordinated response to the introduction of foreign substances 5. Immunology: study the structure of immune system and its functions

Immunity 1.Immunity: : Meaning the state of protection from infectious disease. In 430BC, a plaque in Athens, Those who recovered from the plaque would not contact the disease a second time. 2. Agents: microorganisms (viruses, bacteria etc) and their products, foods, chemicals, pollen, tumor cells, etc. 3.Immune system: immune tissues and organs, immune cells, immune molecules 4.Immune response: collective and coordinated response to the introduction of foreign substances. 5.Immunology: study the structure of immune system and its functions

Immune Response Innate immune response natural immune response non-specific immune response o Adaptive immune response acquirea immune response specific immune response

Immune Response  Innate immune response natural immune response non-specific immune response  Adaptive immune response acquired immune response specific immune response

The innate and adaptive immune response Characteristics Cells Molecules Innate immunity r Responds rapidly / Physical barriers Humoral factors No memory pHagocytes(PMNs Complement rNo or low and macrophages) Acute phase specificity r Natural killer cells Proteins cYtokines Adaptive immunit rEsponds Slowly T cells ANtibodies MEmory rB cells Cytokines r Highly specific Dendritic cells r Granzymes

The innate and adaptive immune response Characteristics Cells Molecules Innate immunity Responds rapidly No memory No or low specificity Physical barriers Phagocytes (PMNs and macrophages) Natural killer cells Humoral factors Complement Acute phase Proteins Cytokines Adaptive immunity Responds Slowly Memory Highly specific T cells B cells Dendritic cells Antibodies Cytokines Granzymes

Innate immunity mechanism of recognition o Pathogen associated molecules patterns(PAMPs): LPS, DNA, RNA, Protein o Danger-associated molecular patterns DAMPS〕: DNA,HSP o Pattern recognition receptors(PrR): Toll-like receptor (TLR), C-lectin recptor(CLR), RIG-1-Like recptor(rlr), NoD-like Receptor(Nlr)

Innate immunity mechanism of recognition  Pathogen associated molecules patterns(PAMPs）:LPS,DNA,RNA,Protein  Danger-associated molecular patterns (DAMPS):DNA,HSP  Pattern recognition receptors (PRR): Toll-like receptor(TLR) ,C-lectin recptor(CLR),RIG-I-Like recptor(RLR),NOD-like Receptor(NLR)

Bacterial product: Flagellin CpG dna Membrane Lipid A lipoproteins TLR: TLR5 TLR9 TLR2 TLR4 Avoidance: N-terminal Prevent Acyl chain amino acid exposure modifications changes