The function and mechanism of mast cell in anti-colon cancer immunity

The function and mechanism of mast cell in anti-colon cancer immunity 陈冠宇、凃康彦、衣欣、董凌云、李桂影、辛雪焕、孙航

The function and mechanism of mast cell in anti-colon cancer immunity 陈冠宇、凃康彦、衣欣、董凌云、李桂影、辛雪焕、孙航

CONTENTS The clinical manifestation of colon cancer A brief introduction involved in the anti 02o he function and mechanism of mast cell involved in anti-colon cancer immuni

CONTENTS The clinical manifestation of colon cancer The function and mechanism of mast cell involved in anti-colon cancer immunity A brief introduction involved in the anti￾colon cancer immune microenvironment

1, There may be no symptom in early stages 2, After tumor ulceration, bleeding, toxin absorption, 1h0 there often appears anemia, low-grade fever of colon s Jesue 3 Cancer in late period can be characterized by abdominal distension and indigestion, and then some sticky mucus

1、There may be no symptom in early stages. 2、After tumor ulceration, bleeding, toxin absorption, there often appears anemia, low - grade fever. 3、Cancer in late period can be characterized by abdominal distension and indigestion, and then some change in defecation habit, abdominal pain, or blood sticky mucus

The microenvironment in anti-tumor immunity 1. cytokines exerting negative effect involved in the anti-colon cancer immunity 2. Cells involved in the anti-colon cancer

The microenvironment in anti-tumor immunity 1. cytokines exerting negative effect involved in the anti-colon cancer immunity 2. Cells involved in the anti-colon cancer

1. cytokines exerting negative effect involved in the anti-colon cancer immunity 护TNF aceto receptor 8p130 EP2/EPA IKK Stat3 MP NF-KB Stat3 IL-6 TNF-Ct NSAIDS

1. cytokines exerting negative effect involved in the anti-colon cancer immunity

()TNF-a-induced NF-KB activation TNF-a-induced NF-KB activation in myeloid cells is important for cancer development, and NF-KB activation in epithelial cells also contributes to tumor formation

(1) TNF-α-induced NF-κB activation TNF-α-induced NF-κB activation in myeloid cells is important for cancer development, and NF-κB activation in epithelial cells also contributes to tumor formation

Toll-Like ceptors E 00 邮邮电如拿邮 MyD88 IRAK TRAFZ TAK1 TRAFZ MEKKs ECSIT Gene Expressio BluB NE-KB pyright 2004 Prote

(2)IL-6 induced the Stat3 activation The Il-6 cytokine family signals through a common receptor, gp130, which activates Stat3 which promotes tumor formation via which transforming growth factor(TGF)- signaling promotes epithelial differentiation P271

(2) IL-6 induced the Stat3 activation The IL-6 cytokine family signals through a common receptor, gp130, which activates Stat3 which promotes tumor formation via which transforming growth factor (TGF)-β signaling promotes epithelial differentiation. P271

Cytokines JAK/STAT Pathway )8 JAKS JAK STAT2 Ga Q P-STAT5 habitation MEKKs EI CIS, SOCs, APPS, TIMP1 Myc, TFs& Cytokines e

2 Cells involved in the anti-colon cancer (1)Nk cell Kills many types of tumor cells, especially cells reduced class I MHC expression and can escape killing by CTL (2)ap T cells lp T cells contains the mhc i restricted CD8+ Ctl and MHC li restricted with CD4+ th cell. The activated CD4+ cells promote the activation of the CTL, and activate the Mg in tumor immunity. After the activation of CTL, kill the tumor cells directly and kill the cytokines(IFN-Y)indirectly (3)Yo T cells Not restricted by Mhc and kill cells that could escape from NK cells

2. Cells involved in the anti-colon cancer (1) NK cell: Kills many types of tumor cells, especially cells reduced classⅠ MHC expression and can escape killing by CTL. (2) αβ T cells: αβ T cells contains the MHCⅠ restricted CD8+ CTL and MHCⅡ restricted with CD4+ Th cell. The activated CD4+ cells promote the activation of the CTL, and activate the MΦ in tumor immunity. After the activation of CTL, kill the tumor cells directly and kill the cytokines (IFN-γ) indirectly. (3) γδ T cells: Not restricted by MHC and kill cells that could escape from NK cells