浙江大学医学院：《免疫学 Immunology》课程教学资源（PPT讲稿）Immunology general

IMMUNOLOGy Immunology general Cai Zhijian, Ph. D caizj@zju.edu.cn Institute of immunology, ZJU

Immunology general IMMUNOLOGY Cai Zhijian, Ph.D caizj@zju.edu.cn Institute of immunology, ZJU

eterences 医学免疫学第6版 人民卫生出版社曹雪涛等 Janeway's Immunobiology 8tn ed Kenneth Murphy Contact information: 0571-88208282 caizj@zju.edu.cn

References • 医学免疫学 第6版 • 人民卫生出版社 曹雪涛等 • Janeway's Immunobiology. 8th ed • Kenneth Murphy Contact information: 0571-88208282 caizj@zju.edu.cn

I Immunity and immunology Il Immunologic function Ⅲ Immune systen IV Immune response V Immunopathology

• Ⅰ Immunity and immunology • Ⅱ Immunologic function • Ⅲ Immune system • Ⅳ Immune response • Ⅴ Immunopathology

Immunity 1. Immunity refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. 2.Agents: microorganismor and their products, foods, chemicals, pollen, tumor cells, viruses 3. Immune system: immune tissues and organs, immune cells, immune molecules 4. Immune response: benefits; damaging effects 6. Immunology: a science studying on organization and function of immune system

Immunity 1.Immunity:refers to all mechanisms used by the body as protection against environmental agents that are foreign to the body. 2.Agents:microorganismor and their products, foods, chemicals, pollen, tumor cells, viruses… 3.Immune system: immune tissues and organs, immune cells, immune molecules 4.Immune response: benefits; damaging effects 5.Immunology：A science studying on organization and function of immune system

Immunologic function Biological effects of immune system on antigens during immune responds a physiological effect Keeping norma homeostasis pathological effect ----resulting in diseases

Immunologic function Biological effects of immune system on antigens during immune responds physiological effect --- keeping normal homeostasis pathological effect ---- resulting in diseases

Physiological and pathological representation of immune response Function Physiological Pathological (advantageous)(harmful) immune defense resist to pathogen hypersensitivity/ immunologic d eficiency disease mmune scavenge damaged Autoimmune homeostasis or senile cell disease Immune Scavenge cells with cancer surveillance misreplication/ virus persistent mutant cell infection

Function Physiological (advantageous) Pathological (harmful) immune defense resist to pathogen hypersensitivity/ immunologic deficiency disease immune homeostasis scavenge damaged or senile cell Autoimmunne disease immune surveillance Scavenge cells with misreplication/ mutant cell Cancer virus persistent infection Physiological and pathological representation of immune response

Immune system a dominate immune function execute immune effect B comprise immune organs, immune cells and immune molecules

Immune system dominate immune function execute immune effect comprise immune organs, immune cells and immune molecules

adenoid right subclavian vein left subclavian vein thymus lymph node heart thoracic duct kidney 身 spleen Peyer's patch in small intestine appendix large intestine lymphatics bone marrow

I Immune organs center immune organs Concept places where immunocytes genesis, develop, differentiate and mature Composition: bone marrow, thymus and bursa of Fabricius(which is one of Avian character) peripheral immune organs Concept: places where mature T, b lymphocytes resident and contact with antigens and carry out Immune response composition: lymph node, spleen, mucosal-associated lymphoid tissue

1 Immune organs center immune organs concept：places where immunocytes genesis, develop, differentiate and mature composition ： bone marrow, thymus and bursa of Fabricius (which is one of Avian character) peripheral immune organs concept ： places where mature T, B lymphocytes resident and contact with antigens and carry out immune response composition：lymph node, spleen, mucosal-associated lymphoid tissue

Bone marrow 1. the place in which proliferation of HSC take place 2. the place in which development and maturation of b cells occur 3. Secondary humoral response and produce antibodies

1. the place in which proliferation of HSC take place 2. the place in which development and maturation of B cells occur 3. Secondary humoral response and produce antibodies Bone marrow