浙江大学医学院：《免疫学 Immunology》课程教学资源（PPT课件）补体系统 Complement System

IMMUNOLOGy complement system 补体系统 Qingqing Wang Institute of Immunology Zhejiang University School of Medicine wqq@zju.edu.cn

complement system 补体系统 IMMUNOLOGY Qingqing Wang Institute of Immunology Zhejiang University School of Medicine wqq@zju.edu.cn

Complement 1. Introduction 2. Activation of the Complement System 3. Regulation of complement activation 4. Biological function of complement system

Complement 1. Introduction 2. Activation of the Complement System 3. Regulation of complement activation 4. Biological function of complement system

Jules bodet (1870-1961) Discoverer of Complement 1894 Bordet发现绵羊抗霍 乱血清能够溶解翟乱弧菌,加 热5630min阻止其活性; 加入新鲜非免疫血清可恢复其 活性。 1919 Nobel prize 百日咳杆菌

Jules Bodet (1870-1961), Discoverer of Complement 1894 Bordet 发现绵羊抗霍 乱血清能够溶解霍乱弧菌，加 热56℃ 30 min 阻止其活性； 加入新鲜非免疫血清可恢复其 活性。 1919 Nobel Prize 百日咳杆菌

Complement Complement (heat-Labile Substance) Destroy Bacteria No Heat Bacteria Complement by Heat but Complement the antibody and Antibody is OK Cell lysis No Cell Lusis Complement, antibodies, and cellular antigens are required for cell lysis

Complement

Complement Introduction Complement(c) A group of serum proteins involved in the control of inflammation the activation of phagocytes and the lytic attack on cell membranes This activity is destroyed (inactivated) b heating serum at 56C for 30 minutes Complement System consists of a large number of proteins which become enzymes after being activated

Introduction Complement (C) ➢ A group of serum proteins involved in the control of inflammation, the activation of phagocytes and the lytic attack on cell membranes. ➢ This activity is destroyed (inactivated) by heating serum at 56C for 30 minutes . Complement System consists of a large number of proteins which become enzymes after being activated. Complement

Complement I. Proteins of the complement System 1. Activation proteins 2, Regulatory proteins 3. Complement receptor

1. Activation proteins 2. Regulatory proteins 3. Complement receptor Complement I. Proteins of the Complement System

b是大片段,a是小片段 abul k abbas, adrew h lichtman shiy pillai Cellular and Molecular Immunology. Saunders ELSEVIER 6th edition 医学免疫学,人民卫生出版社,第四版 第五版..C2特殊,C2a是大片段

b是大片段，a是小片段 Abul K. Abbas, Adrew H. Lichtman, Shiv Pillai. Cellular and Molecular Immunology. Saunders ELSEVIER, 6th edition 医学免疫学，人民卫生出版社，第四版 第五版… C2特殊，C2a是大片段

Complement Activation proteins r Classical pathway: Clq, clr, c1s C4,C2 r MBL pathway: MbL, MASP r Alternative pathway: factor B,D r Terminal pathway: C3, C5, C6, C7, c8,c9

Activation Proteins Classical pathway: C1q, C1r, C1s, C4, C2 MBL pathway: MBL, MASP Alternative pathway: factor B, D Terminal pathway: C3, C5, C6, C7, C8, C9 Complement

Complement Regulatory Proteins F CIINH, C4bp, factor I, factor H rS protein, membrane cofactor protein r decay-accelerating factor (DAF) ■■■ Complement receptor f CRINCR5, CaR, car, caru

Regulatory Proteins C1INH, C4bp, factor I, factor H S protein, membrane cofactor protein decay-accelerating factor (DAF) … Complement receptor CR1~CR5, C3aR, C2aR, C4aR… Complement

Complement II. Complement producing cells r Liver hepatocytes r Monocytes/Macrophages r Epithelial cells

II. Complement producing cells Liver hepatocytes Monocytes/Macrophages Epithelial cells Complement