《医学细胞生物学》课程教学资源（PPT课件讲稿）第二篇 细胞的结构与功能 Cellular structures and their functions Part II Cellular structure and their functions

第二篇细胞的结构与功能 Cellular structures and their functions Location, structure+ Molecular components Function Life activity of cell and life phenomena To be simplified: birth, aging, illness and death Including: cell differentiation, growth and division, mobility, inheritance and mutation, metabolisms in energy and material, response to stimuli from outside the cell cell senescence and death 具体说包括细胞的分化、生长与分裂、细胞的运动、遗传与变异、细胞的 物质与能量代谢、细胞对外界刺激的应答、细胞的衰老与死亡

Location, structure Molecular components Function 第二篇 细胞的结构与功能 Life activity of cell and life phenomena To be simplified: birth, aging, illness and death Including: cell differentiation, growth and division, mobility, inheritance and mutation, metabolisms in energy and material, response to stimuli from outside the cell, cell senescence and death. 具体说包括细胞的分化、生长与分裂、细胞的运动、遗传与变异、细胞的 物质与能量代谢、细胞对外界刺激的应答、细胞的衰老与死亡。 Cellular structures and their functions

Part l cellular structure and their functions Cell membrane and transmembrane transportation Endomembrane system and vesicle transport Mitochondria and energy transformation Nuclei Cytoskeleton and cell movement Cell junctions and cell adhesion Extracellular matrix and its functions

Part II Cellular structure and their functions Cell membrane and transmembrane transportation Endomembrane system and vesicle transport Mitochondria and energy transformation Nuclei Cytoskeleton and cell movement Cell junctions and cell adhesion Extracellular matrix and its functions

Chapter 4 Cell membrane and transmembrane transportation Membrane bilayer 00000000 00 (b) Polar head Hydrophobic lipid protein molecules molecule Polar head groups

Chapter 4. Cell membrane and transmembrane transportation

Q p bilayer (5 nm) lipid molecule protein molecule

Chemical com ponents of membrane Across membrane transport of small molecules Across mem brane transport of large molecules Cell membrane and particles Cell surface and its specified structure Abnormality of cell membrane and diseases

Chemical components of membrane Across membrane transport of small molecules Across membrane transport of large molecules and particles Cell surface and its specified structure Abnormality of cell membrane and diseases Cell membrane

Section 1. Chemical components of cell Membrane and their molecular structure 1.Chemical components of cell membrane (1) lipids constitute the skeleton of the membrane phospholipids 膜脂( membrane lipid){ cholesterol glycolipid

Section 1. Chemical components of cell Membrane and their molecular structure 1.Chemical components of cell membrane （1）lipids constitute the skeleton of the membrane 膜脂（membrane lipid） phospholipids cholesterol glycolipid

Section 1. Chemical components of cell Membrane and their molecular structure 1.Chemical components of cell membrane (1) lipids constitute the skeleton of the membrane phospholipids 膜脂( membrane lipid){ cholesterol glycolipid

Section 1. Chemical components of cell Membrane and their molecular structure 1.Chemical components of cell membrane （1）lipids constitute the skeleton of the membrane 膜脂（membrane lipid） phospholipids cholesterol glycolipid

-NICH, CHOLINE (hydrophilic) PHOSPHATE head group GLYCEROL P-= hydrophilic C=o C=o hydrophobic tails CH, CH2 nonpolar (hydrophobic <53oz= CH, CH, CH, CH cis-double bond 叫叫叫叫

PE PS PC CH CH NH 3 CH3 NH cH∠CH3 CH2 -coo O CH CH CH2 CH2 o=P-0 o=P-0 o=p-0⊙ OH OH cH2一H一cH2 cH2一CH一CH cH2一H一cH2 cH一CH一cH2 CH-CH CH NH O =0c=0 =oc=0 CH >区 H > U> > phosphatidyl- phosphatidyl- phosphatidyl- sphingomyelin sphingosine ethanolamine serine choline E Figure 10-3 Molecular Biology of the Cell(@ Garland Science 2008)

Figure 10-3 Molecular Biology of the Cell (© Garland Science 2008) PE PS PC

PE PS PC CH CH 3 CH3 NH NH cH∠CH3 CH2 -coo O CH CH CH2 CH2 o=P-0 o=P-0 o=p-0⊙ 0⊙ OH OH cH2一H一cH2 cH2一CH一CH cH2一H一cH2 cH一CH一cH2 Hc一cH-cH2 CH NH O =0c=0 =oc=0 CH >区 H > U> > phosphatidyl- phosphatidyl- phosphatidyl- sphingomyelin sphingosine ethanolamine serine choline E Figure 10-3 Molecular Biology of the Cell(@ Garland Science 2008)

Figure 10-3 Molecular Biology of the Cell (© Garland Science 2008) PE PS PC