《病理生理学 Pathophysiology》课程PPT教学课件（英文版）Chapter 9 Coagulation-anticoagulation balance & imbalance of haemostatic system

Chapter 9 Coagulation-anticoagulation balance imbalance of haemostatic system Zhao mingyao BMC.ZZU

Zhao Mingyao BMC.ZZU Coagulation-anticoagulation balance & imbalance of haemostatic system Chapter 9

Red blood cell Brokenblood wessel wall Platelet Activated platelet Clot Fibrin

Section 1 Overview of haemostatic system Thrombin Plasmin Fibrin FDP Coagulation and blood flowing

Section 1 Overview of haemostatic system Thrombin Fibrin Plasmin ? FDP . . . . . Coagulation and blood flowing

Fibrinogen Thrombin Fibrin mesh Factor Xf Crosslinked fibrin mesh Other FDPs D-dimer Pasir Clot formation(electron microscope)

Clot formation (electron microscope)

Contact activation X v ATⅢ Protein S prothrombin-- thrombin ATⅢl APC fibrinogen FDP terrin Protein C TM endotheliul liver FDP fibrin U-PA HPAl-I aminogen plasmin (D-dimer a2antpasmun

TF liver endothelium TM

Complex formation of clotting factors MEMBRANE PHOSPHOLIPID- DEPENDENT REACTIONS NBL。oDc。 AGULAT|oN PIt Ⅷ、ⅸ、Ca2++plt aet。rX Ⅹ、V、Ca2+plt o rfn avul

Ⅷ、Ⅸ、Ca2+ + plt Ⅹ、Ⅴ、Ca2+ + plt Complex formation of clotting factors Plt

3 steps of coagulation 1. Prothrombin activator formation 2. Thrombin formation Contact actat 3. Fibrin formation

1.Prothrombin activator formation 2. Thrombin formation 3.Fibrin formation 3 steps of coagulation

Section 2 Imbalance in haemostatic system

Section 2 Imbalance in haemostatic system

balance imbalance of Coagulation-anticoagulation Coagulation system Anticoagulation system VEc TFPI, PC, PS, Extrinsic Intrinsic AT-II, Heparin system system Microcirculation fibrinolysis TF XIa other factor Coagulation status Change

Coagulation system Extrinsic system Intrinsic system Anticoagulation system VEC Microcirculation TFPI, PC, PS, AT-III , Heparin Coagulation status Change TF XIIa other factor fibrinolysis balance & imbalance of Coagulation-anticoagulation

Major types 1. Bleeding disorder inherited acquired 2. Thrombogenesis and thrombotic disorders 3. Blood vessel abnormity: VEC. Factors activation 4. Fibrinolytic factors abnormity

Major types 1.Bleeding disorder: inherited ~ & acquired ~ 2.Thrombogenesis and thrombotic disorders 3.Blood vessel abnormity: VEC, Factors activation 4.Fibrinolytic factors abnormity