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吉林大学:《药理学》课程PPT教学课件(七年制)Macrolides(Erythromycin)

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吉林大学:《药理学》课程PPT教学课件(七年制)Macrolides(Erythromycin)
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Macrolides(Erythromycin 【Antibacterial activity】 1.Erythromycin is bacteriostatic 2.It is effective against gram-positive organisms 3.It is active against some gram-negative organisms 4.Mycoplasma,Chlamydiae,Legionella are susceptible

Macrolides(Erythromycin ) 【Antibacterial activity 】 1. Erythromycin is bacteriostatic 2. It is effective against gram-positive organisms 3. It is active against some gram-negative organisms 4. Mycoplasma, Chlamydiae, Legionella are susceptible

Vancomycins 【Antibacterial activity】 1.It is bactericidal agent 2.It is primarily active against gram-positive bacteria (MRSA),but enterococci are resistant 3.Gram-negative bacilli are resistant to vancomycin

Vancomycins 【Antibacterial activity 】 1. It is bactericidal agent 2. It is primarily active against gram-positive bacteria (MRSA),but enterococci are resistant 3. Gram-negative bacilli are resistant to vancomycin

Aminoglycosides

Aminoglycosides

Mechanism of action】 Decoding interfere with the initiation complex nonfunctional or toxic protein synthesis 人 aminoglycosides(30S,A) breakup of polysomes into nonfunctional monosomes

P A P A P A interfere with the initiation complex nonfunctional or toxic protein synthesis P A breakup of polysomes into nonfunctional monosomes 【Mechanism of action】

Tetracyclines and Chloramphenicol Section 1 Tetracyclines

Tetracyclines and Chloramphenicol Section 1 Tetracyclines

【Adverse effect】 1.Gastric discomfort:Nausea,vomiting,and diarrhea 2.Bony structures and Teeth discoloration and hypoplasia of the teeth and a temporary stunting of growth 3.Fatal hepatotoxicity:in pregnant women 4.Phototoxicity:severe sunburn

【Adverse effect 】 1. Gastric discomfort: Nausea, vomiting, and diarrhea 2. Bony structures and Teeth :discoloration and hypoplasia of the teeth and a temporary stunting of growth 3. Fatal hepatotoxicity: in pregnant women 4. Phototoxicity: severe sunburn

4.Vestibular problems:dizziness,nausea,vomiting 5.Pseudotumor cerebri:Benign intracranial hypertension headache,blurred vision 6.Superinfections:pseudomembranous enterocolitis Vancomycin:

4. Vestibular problems: dizziness, nausea, vomiting 5. Pseudotumor cerebri: Benign intracranial hypertension , headache , blurred vision 6. Superinfections: pseudomembranous enterocolitis Vancomycin:

Section 2 Chloramphenicol Antibacterial action 1.Chloramphenicol is either bacteriostatic or bactericidal 2.It is active against both aerobic and anaerobic gram- positive and gram-negative organisms 3.It has effective against rickettsiae,helicoids,Chlamydia and mycoplasma

Section 2 Chloramphenicol 【 Antibacterial action】 1. Chloramphenicol is either bacteriostatic or bactericidal 2. It is active against both aerobic and anaerobic gram￾positive and gram-negative organisms 3. It has effective against rickettsiae, helicoids, Chlamydia and mycoplasma

【Mechanism of action】 Chloramphenicol(50S,A) Peptidyl transferase

P A P A Chloramphenicol(50S,A) 【Mechanism of action】

【pharmacokinetics】 1.Chloramphenicol may be administered either intravenously or orally 2.It penetrate blood-brain barrier,placental barrier, blood-ocular barrier 3.It is inactivated by conjugation with glucuronic acid in liver,secreted by the renal tubule

【pharmacokinetics】 1. Chloramphenicol may be administered either intravenously or orally 2. It penetrate blood-brain barrier, placental barrier, blood-ocular barrier 3. It is inactivated by conjugation with glucuronic acid in liver, secreted by the renal tubule

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