吉林大学：《药理学》课程PPT教学课件（七年制）Neuroleptic drugs

Neuroleptic drugs

Neuroleptic drugs

Overview Antischizophrenic drugs,antipsychotic drugs,or major tranquilizers Manic states and delirium

Overview ◼ Antischizophrenic drugs, antipsychotic drugs, or major tranquilizers ◼ Manic states and delirium

Different Types of Synapses Axosomatic Neuron Axodendritic Axoaxonic

Prasynaptic Transmitter Reuptake into axon terminal ⑦ Dockin 1.Calcium ⑧Glial Uptake Na 4 G-protein coupled Depolarization Glial cell receptor Transmitter binds postsynaptic receptor Postsynaptic and opens a sodium channel

Cytoplasm Dendrites Cell Body I'elodendria Node of Ranvier Axon Axoplasm

Neuron Nerve Axon Myelin sheath

schizophrenia Is a particular type of psychosis ■( Characterized by delusions, hallucinations,and thinking or speech disturbances. Has a strong genetic component An overactivity of the mesolimbic depaminergic neurons

schizophrenia ◼ Is a particular type of psychosis ◼ Characterized by delusions, hallucinations, and thinking or speech disturbances. ◼ Has a strong genetic component ◼ An overactivity of the mesolimbic depaminergic neurons

Neuroleptic drugs Five major classifications based on the structure of the drug. Phenothiazines:chlorpromazine, fluphenazine,et al. Dibenzodiazepines:clozapine

Neuroleptic drugs ◼ Five major classifications based on the structure of the drug. ◼ Phenothiazines: chlorpromazine, fluphenazine, et al. ◼ Dibenzodiazepines: clozapine

Mode of action Dopamine receptor-blocking activity in brain:D1-D5 receptors Antagonized by agents that raise dopamine concentration Serotonin receptor-blocking activity in brain:atypical agents appear to exert part of their unique action through inhibition of S receptors

Mode of action ◼ Dopamine receptor-blocking activity in brain: D1-D5 receptors Antagonized by agents that raise dopamine concentration ◼ Serotonin receptor-blocking activity in brain: atypical agents appear to exert part of their unique action through inhibition of S receptors

Dopamine drugs Dopamine ee8sa8o8ked DECREASED INTRACELLULAR RESPONS目 B Figure 13.2 Dopamine-blocking actions of neuroleptic drugs