吉林大学：《药理学》课程PPT教学课件（七年制）Anticancer Drug

Anticancer Drug Section I Basic Pharmacology of Anticancer Drug 1.Classification

1 Anticancer Drug Section I Basic Pharmacology of Anticancer Drug 1. Classification

(1)According to chemical constitution and resource a.Alkylating agent b.Antimetabolites c.Antibiotics d.Plant-derived products e.Hormonal agent

2 (1) According to chemical constitution and resource a. Alkylating agent b. Antimetabolites c. Antibiotics d. Plant-derived products e. Hormonal agent

Alkylating agent Cyclophosphamide Mechlorethamine Melphalan Chlorambucil

3 Alkylating agent Cyclophosphamide Mechlorethamine Melphalan Chlorambucil

Antimetabolites Folic acid analogue:methotrexate Pyrimidines:fluorouracil,cytarabine Purines:thioguanine,mercaptopurine

4 Antimetabolites Folic acid analogue: methotrexate Pyrimidines:fluorouracil, cytarabine Purines: thioguanine, mercaptopurine

Antibiotics Anthracyclines Dactinomycin Bleomycin Mitomycin

5 Antibiotics Anthracyclines Dactinomycin Bleomycin Mitomycin

Plant-derived products Vinca alkaloids Etoposides Taxanes

6 Plant-derived products Vinca alkaloids Etoposides Taxanes

Hormonal agent Hormone antagonists Hormone agonists

7 Hormone antagonists Hormone agonists Hormonal agent

(2)According to biochemistry mechanisms of antitumor effect a.Agents affecting biosynthesis of nucleic acid b.Agents affecting structure and function of DNA c.Agents affecting transcription process and interrupting synthesis of RNA d.Agents interfering with the formation and function of proteins. e.Agents affecting hormone homeostasis

8 （2）According to biochemistry mechanisms of antitumor effect a. Agents affecting biosynthesis of nucleic acid b. Agents affecting structure and function of DNA c. Agents affecting transcription process and interrupting synthesis of RNA d. Agents interfering with the formation and function of proteins. e. Agents affecting hormone homeostasis

2.Mechanism of pharmacologic action (1)Cell biology mechanisms of antitumor effect (2)Biochemistry mechanisms of antitumor effect

9 2. Mechanism of pharmacologic action （1） Cell biology mechanisms of antitumor effect （2） Biochemistry mechanisms of antitumor effect

(1)Cell biology mechanism of antitumor effect a.Cell Cycle-Nonspecific (CCNS)Agents: Alkylating agent,Antibiotics, Platinum antitumor compound a.Cell Cycle-Specific (CCS)Agents: Methotrexate:S phase Vinca alkaloid:M phase

10 （1） Cell biology mechanism of antitumor effect a. Cell Cycle-Nonspecific (CCNS) Agents: Alkylating agent, Antibiotics, Platinum antitumor compound a. Cell Cycle-Specific (CCS) Agents: Methotrexate: S phase Vinca alkaloid: M phase