中国高校课件下载中心 》 教学资源 》 大学文库

《儿科学》课程教学课件(PPT讲稿)15 Congenital Hypothyroidism

文档信息
资源类别:文库
文档格式:PPTX
文档页数:63
文件大小:12.6MB
团购合买:点击进入团购
内容简介
《儿科学》课程教学课件(PPT讲稿)15 Congenital Hypothyroidism
刷新页面文档预览

Congenital Hypothyroidism(Cretinism)

(Cretinism) Congenital Hypothyroidism

LearningobjectivesYoushould know:The clinical features of congenitalhypothyroidism in neonates and childrenBe able to discussthe diagnosis andmanagement

Learning objectives You should know: The clinical features of congenital hypothyroidism in neonates and children Be able to discuss the diagnosis and management

Major contentsOverview of congenitalhypothroidismEtiologyClinical manifestationLaboratory examinationDiagnosis and differential diagnosisTreatment

Major contents Overview of congenital hypothroidism Etiology Clinical manifestation Laboratory examination Diagnosis and differential diagnosis Treatment

AbbreviationCHcongenital hypothyroidismTRHthyrotropin-releasing hormoneTSHthyrotropic-stimulatinghormoneT4thyroxineT3triiodothyronineMITmonoiodotyrosineDITdiiodotyrosineTGthyroglobulinTBGthyroxine-binding globulin

Abbreviation CH congenital hypothyroidism TRH thyrotropin-releasing hormone TSH thyrotropic-stimulating hormone T4 thyroxine T3 triiodothyronine MIT monoiodotyrosine DIT diiodotyrosine TG thyroglobulin TBG thyroxine-binding globulin

OverviewHypothyroidismCongenital hypothyroidismacquired hypothyroidismIodine deficiencyAutoimmunediseaseHashimoto thyroiditis

Overview Hypothyroidism Congenital hypothyroidism acquired hypothyroidism Iodine deficiency Autoimmune disease— Hashimoto thyroiditis

OverviewHypothyroidismCongenital hypothyroidismacquiredhypothyroidismIodine deficiencyAutoimmunediseaseHashimotothyroiditis

Overview Hypothyroidism Congenital hypothyroidism acquired hypothyroidism Iodine deficiency Autoimmune disease— Hashimoto thyroiditis

OverviewCongenitalHypothyroidismiscommondisease of pediatric endocrinology.Congenital factors cause the insufficiency of thyroidhormone, which result in the low metabolism,growth retardation, and mental impairment.The onset during inborn or newborn period, canlead to irreversible mentalimpairment.One of the few preventable disease, earlytreatment can improve prognosisthoroughly

Overview Congenital Hypothyroidism is common disease of pediatric endocrinology. Congenital factors cause the insufficiency of thyroid hormone, which result in the low metabolism, growth retardation, and mental impairment. The onset during inborn or newborn period, can lead to irreversible mentalimpairment. One of the few preventable disease, early treatment can improve prognosisthoroughly

Incidence1 in 4000livebirths(AmericaandEurope)Females 2: Male 1InChinaIncidenceofCongenital hypothyroidismFromthe neonatalscreening): 1 in 3624-----the nationwide neonatal screening fromclinical examination center of Health Bureau in1999

Incidence 1 in 4000 live births (America and Europe) Females 2: Male 1 In China: Incidence of Congenital hypothyroidism (From the neonatalscreening): 1 in 3624 -the nationwide neonatal screening from clinical examination center of Health Bureau in1999

Enbr yol ogy of Thyr oidPrimaryThyroid is the first endocrine gland in embryotympaniccavityto developPharyrxBegins toform in 24days afterfloorfertilizationExternalauditorymeatusFormsfromprimordialpharyngealfloor(原始咽底部)forming thyroid diverticulum(憩室)UItimobranchialbody(from4pouch)As embryo grows and tongue grows, thyroiddescendsinanteriorneck and reaches itsParathyroidgland (trom 3"pouch)normalposition--opposite cervical vertebra5-7by7weeksof gestationThymus(from3"pouch)

Embr yol ogy of Thyr oi d • Thyroid is the first endocrine gland in embryo to develop • Begins to form in 24 days after fertilization • Forms from primordial pharyngealfloor(原 始咽底部) forming thyroid diverticulum (憩室) • As embryo grows and tongue grows, thyroid descends in anterior neck and reaches its normal position ——opposite cervical vertebra 5-7 by 7 weeks of gestation Pharynx floor

RoleofPlacentaSubstancePlacental permeabilityI-++++TRH+++IgG Antibodies+++T3+T4TSH0

Role of Placenta Substance Placental permeability I- ++++ TRH +++ IgG Antibodies +++ T3 + T4 + TSH 0

刷新页面下载完整文档
VIP每日下载上限内不扣除下载券和下载次数;
按次数下载不扣除下载券;
注册用户24小时内重复下载只扣除一次;
顺序:VIP每日次数-->可用次数-->下载券;
相关文档