安徽医科大学：《医学细胞生物学》课程教学资源（课件讲稿，打印版）Nucleus

Nucleus peripheral heterochromatin endoplasmic reticulum DNA and associated nudear proteins(chromatin), envelope plus many RNA and protein molecules nucleolus nucleolus centrosome microtubule nuclear lamina nuclear pore 1 wm outer nuclear membrane nuclear (A) 2um (B) inner nuclear membrane envelope This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more informatior

Outline 1.Nuclear envelope and nuclear pore complex. 2.Chromatin and chromosome. 3.Nucleolus. 4.Nuclear matrix. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Double-membrane Outer nuclear nuclear envelope membrane Nuclear envclopo Nuclear lamina Inner nuclear surrounds the Nucleolus membrane Perinuclear space nucleus Chromatin Ribosomes The biggest and most important organelle of eukaryotic cell. Consists of four parts: Nuclear envelope, chromatin,nucleolus, Nuclear pores nuclear matrix. CYTOSOL Rough ER This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

The structure of nucleus peripheral heterochromatin endoplasmic reticulum DNA and associated proteins(chromatin), plus many RNA and protein molecules nucleolus centrosome microtubule nuclear lamina nuclear pore 1um outer nuclear membrane nuclear inner nuclear membrane envelope A cross-sectional view of a typical cell nucleus. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

The structural organization of nucleus and nuclear envelope nuclear envelope nuclear pore lamina condensed chromatin nucleus 1 um This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Section 1.Nuclear Envelope 1.The composition of nuclear envelope What are the characteristics of its composition? 1.Protein:Similar to ER,lamina on inner membrane. 2.Lipids:Similar to ER. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

2.The structure of nuclear envelope Outer membrane Perinuclear Inner membrane Smooth space endoplasmic reticulum Ribosomes Nuclear Nuclear Nucleolus Chromatin Rough pore complex lamina endoplasmic reticulum This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

The nuclear envelope consists of two concentric membranes by a perinuclear space. The inner surface of the nuclear envelope is lined by the nuclear lamina: >The nuclear lamina supports the nuclear envelope:Gives shape and stability of nuclear envelope;Provides a structure link between chromatin and nuclear envelope; >The nuclear lamina is composed of lamins; >The integrity of the nuclear lamina is regulated by phosphorylation and dephosphorylation. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

>The phosphorylation of the lamins triggers the disassembly of the nuclear lamina,which in turn cause the nuclear envelope to break up into vesicles.Dephosphorylation of the lamins helps reverse the process. >Old nuclear envelope reforms new nuclear envelope. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Lamin Nuclear lamina filament (核纤层) 200000008C 0000o8 Lamin tetramer MPF CP PO 1 um Phosphorylated lamin dimers This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information