安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)08-Genetics of Common Disorders with Complex Inheritance
Medical Genetics Chapter 8 Genetics of Common Disorders with Complex Inheritance This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics Outline Multifactorial inheritance; Qualitative and quantitative traits; Genetic analysis of qualitative disease traits; Determining the relative contributions of genes and environment to complex disease; Genetic analysis of quantitative traits. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 1.Multifactorial inheritance Multifactorial/complex inheritance result from complex interactions between a number of genetic and environmental factors. o many different genes(major gene,minor gene), many environmental factors. o gene-gene interaction, gene-environment interactions. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 2.Qualitative and quantitative traits ◆( Qualitative traits:a genetic disease that is either present or absent is referred to as a discrete or qualitative trait;one has the disease or not. Quantitative traits:measurable physiological or biochemical quantities such as height,blood pressure,serum cholesterol concentration,and body mass index(a measure of obesity)that underlie many common and devastating illnesses in the population. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 2.1 Genetic Analysis of Qualitative Disease Traits Familial aggregation:affected individuals may cluster in families. Concordance and discordance:when two related individuals in a family have the same disease,they are said to be concordant for the disorder.Conversely,when only one member of the pair of relatives is affected and the other is not, the relatives are discordant for the disease. genocopy phenocopy This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics Measuring familial aggregation in qualitative traits ① Relative Risk入r Prevalence of the disease in the 入= relatives of an affected person Prevalence of the disease in the general population The value of Ar is a measure of familial aggregation that depends both on the risk of the disease's recurrence in the family and on the population prevalence; ◆the larger入ris,the greater is the familial aggregation. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics ◆ Measuring familial aggregation in qualitative traits ① Relative Risk入r ② Case-control studies: Patients with a disease(the cases)are compared with suitably chosen individuals without the disease(the controls),with respect to family history of disease(as well as other factors,such as environmental exposures, occupation,geographical location,parity,and previous illnesses). This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 2.2 Determining the relative contributions of genes and environment to complex disease ◆ Concordance and allele sharing among relatives Unrelated family member controls ◆Twin studies This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 2.3 Genetic analysis of quantitative traits The normal distribution Mean 14 10 (spuesnou)uew jo eqwnN 6 2 SD below 2 SD above the mean the mean 2 1 55 60 65 70 75 80 Stature(inches) Elsevier.Nussbaum et al:Thompson and Thompson's Genetics in Medicine 7e-www.studentconsult.com This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
Medical Genetics 2.4 Familial aggregation of quantitative traits ◆Heritability Variance in DZ pairs-Variance in MZ pairs Variance in DZ pairs The higher the heritability,the greater is the contribution of genetic differences among people in causing variability of the trait. ●h2 varies from0to1. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information
This document is produced by trial version of Print2Flash. Visit www.print2flash.com for more information
按次数下载不扣除下载券;
注册用户24小时内重复下载只扣除一次;
顺序:VIP每日次数-->可用次数-->下载券;
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)06-clinical cytogenetics 02 disorders of the autosomes and the sex chromosomes.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)06-clinical cytogenetics 01 disorders of the autosomes and the sex chromosomes.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)05-principles of clinical cytogenetics.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)02-The Human Genome and the Chromosomal Basis of Heredity.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)01-Introduction to medical genetics.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Programmed cell death and cell senescence.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Cell division and cell cycle.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Extracellular matrix.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Cell signaling.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Cell junction and cell adhesion.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Nucleus.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Cytoskeleton.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Endomembrane system and vesicle transport.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Membrane transport.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Cell membrane.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)The unity and diversity of cells.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(课件讲稿,打印版)Introduction.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(实践指导,打印版)微丝的形态结构观察.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(实践指导,打印版)细胞内碱性蛋白的显示.pdf
- 安徽医科大学:《医学细胞生物学》课程教学资源(实践指导,打印版)细胞器的分级分离.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)07-patterns of single-gene inheritance.pdf
- 安徽医科大学:《医学遗传学》课程教学资源(课件讲稿,打印版)09 Genetic Variation in Individuals and Population.pdf
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第一章 绪论(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第三章 外源化学物在体内的生物转运与生物转化(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第二章_毒理学基本概念(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第五章 毒作用影响因素(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第六章 外源化学物的一般毒性作用(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第七章 外源化学物致突变作用(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第九章 发育毒性与致畸作用(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第八章_外源化学物致癌作用(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)复习题一.doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)第十一章 管理毒理学(含答案).doc
- 安徽医科大学:《毒理学基础》课程教学资源(试卷习题)复习题二.doc
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)转基因技术 Genetically modified animals(主讲:章志国).pptx
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)精子发生的分子机制(主讲:朱复希).ppt
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)胚胎的培养(主讲:章志国).pptx
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)人类配子、胚胎和性腺组织的冷冻(主讲:郝燕).pptx
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(电子教案)生殖医学相关的分子生物技术.doc
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)辅助生殖伦理的基本常识与基本原则(主讲:周平).pptx
- 安徽医科大学:《生殖医学基础与临床》课程教学资源(PPT课件讲稿)人工授精 artificial insemination(主讲:邹薇薇).pptx