安徽医科大学：《医学细胞生物学》课程教学资源（课件讲稿，打印版）Cell membrane

4-1 Cell Membrane Fibers of Carbohydrate EXTRACELLULAR extracellular FLUID matrix (ECM) Glycoprotein Glycollpid Filaments of Cholesterol cytoskeleton Peripheral Integral protein protein CYTOPLASM 100 Addipon Wealey Lengman ine. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Cell Membrane (Plasma Membrane) lipid bilayer (5nm) (A) lipid molecule protein molecule lipid (C) (B) protein molecules molecule A.An electron micrograph of a plasma membrane of a human red blood cell. B.Two-dimensional and three-dimensional views of a cell membrane. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Cell Biomembrane(生物膜) membrane Cytoplasm Plasma membrane Unit membrane structure (under electron microscope) Internal membranes (endomembrane) Endoplasmic Reticulum -Golgi complex Lysosome Peroxisome Mitochondrion This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Cell Membrane A membrane encloses cell defining the cell extent and maintaining the endo-enviroment of cells. (Also names plasma membrane) Structure: Assemblies of lipid and protein molecules. Function: A barrier between interior and exterior of the cell. Transmit material,energy,and signals. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Outline Structural organization and basic composition of plasma membrane. Membrane lipids; Membrane proteins; Membrane carbohydrates; Basic characteristics and functions of plasma membrane. Fluidity of membrane; Asymmetry of membrane. Structure models of plasma membrane. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

I.Structure organization and basic composition of plasma membrane 1.Membrane lipids -continuous double layer 磷脂(phospholipid) (1)甘油磷脂(phosphoglycerides) phosphatidylcholine(PC) phosphatidylserine(PS) phosphatidylethanolamine(PE) phosphatidylinositol (Pl) (2)鞘磷脂(sphingomyelin,SM) ■ 胆固醇(cholesterol) 糖脂(glycolipid) This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

☆Amphipathic molecule(双亲性分子) Molecule has both hydrophilic(亲水性)and hydrophobic(疏水性)parts. shape of lipid packing of lipid molecule molecules lipid micelle wate lipid bilayer (A) (B) Packing arrangements of lipid molecules in an aqueous environment. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Lipids:amphipathic molecules(双亲性分子) Polar end Choline (hydrophilic) （亲水性) 0 CH2-CH-CH2 Glycerol 0 0 c-0 C=O Nonpolar end (hydrophobic) (疏水性) This document is produced by trial version of Print2Flash.Visit www.printflash.com for more information

1.1 Phospholipids(磷脂) H2一NCHh CHOLINE polar (hydrophilic) PHOSPHATE head group GLYCEROL hydrophilic head =0 0 hydrophobic 1 2 tails (D) nonpolar cis-double (hydrophobic) bond tails HYDROCARBON TAIL HYDROCARBON TAIL c (A) (B) (C) This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information

Lipids Bilayer Basic structure of plasma membrane. ENERGETICALLY UNFAVORABLE Serine Phosphate Hydrophilic heads interact with water planar phospholipid bilayer with edges exposed to water Hydrophobic tails interact with each other sealed compartment Hydrophilic heads interact with water formed by phospholipid bilayer ENERGETICALLY FAVORABLE The closed structure is stable because it avoids the exposure of the hydrophobic tails to water,which would be energetically unfavorable. This document is produced by trial version of Print2Flash.Visit www.print2flash.com for more information