复旦大学：《医学微生物学 Medical Microbiology（MBBS）》课程讲义_讨论稿_04 STD's and Animal Diseases

B.1.P 123RF STD's and Animal Diseases Eric LU,Eric Tse,Simon Xie,Marten Tan,Steven Wang

Eric Lu, Eric Tse, Simon Xie, Marten Tan, Steven Wang

Viral sTDs

120 160 Matrix protein(p17) HIV Capsid protein(p24 Protease Retroviral rna reverse transcriptase/ Integrase proteins Attacks t cells Lipid bilayer membrane Envelop capsid, dna RNA dimer Sex, blood birth HTLV-1- first discovered retrovirUs 1977

Retroviral RNA Attacks T cells Envelop, capsid, DNA Sex, blood, birth HTLV-1- first discovered retrovirus 1977 HIV

HIV Pathogenesis GP16o attaches to CD4 receptor T HELPER, monocytes, macrophages Replication, processing, budding Reverse transcriptase, Integrase, Protease Gradual destruction oft-cells AIDS diagnosed when T-cell count latency ->opportunistic infection

GP160 attaches to CD4 receptor • T HELPER, monocytes, macrophages Replication, processing, budding • Reverse transcriptase, Integrase, Protease Gradual destruction of T-cells AIDS diagnosed when T-cell count latency -> opportunistic infection HIV Pathogenesis

Associated with Candida albicans, PCP, Kaposi's Sarcoma, TB, EBV, CMV, Fungi Diagnosis-ELISA, PCR, Western Blot No Cure, or Vaccine-(rapid mutation Antiretroviral drugs

Associated with: Candida albicans, PCP, Kaposi’s Sarcoma, TB, EBV, CMV, Fungi Diagnosis- ELISA, PCR, Western Blot No Cure, or Vaccine- (rapid mutation) • Antiretroviral drugs

Herpes viruses Lots of comonly seen diseases dsRNA, enveloped Latent State-reside in the sensory ganglia Cell mediated immune response SimplexvirUs-direct contact of mucous membranes birth HSV-1-cold sores, HSv-2-genital herpes Gingivostomatitis, genital herpes

Lots of comonly seen diseases dsRNA, enveloped Latent State- reside in the sensory ganglia Cell mediated immune response Simplexvirus- direct contact of mucous membranes, birth • HSV-1- cold sores, HSV-2- genital herpes • Gingivostomatitis, genital herpes Herpes Viruses

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Mononucleosis EBV-Epstein- Barr Virus Affects lymphocytes-fever, chills, sweats, painful pharyngitis, malaise Invades b cells-inducing abnormal growth (cancer) Associated with Burkitt's lymphoma Monospot test for diagnosis

EBV- Epstein- Barr Virus Affects lymphocytes- fever, chills, sweats, painful pharyngitis, malaise. •Invades B cells- inducing abnormal growth (cancer) •Associated with Burkitt’s lymphoma •Monospot test for diagnosis Mononucleosis

CMv-cytomegalovirUs-named after swollen cells Congenital, milk, saliva, urine tears sex Diagnosis- Buffy Coat, PCR

CMV- cytomegalovirus- named after swollen cells •Congenital, milk, saliva, urine, tears, sex •Diagnosis- Buffy Coat, PCR

Human Papilloma virus Circular dsDna Over so strains Warts-skin larynx, cervix, mucosa SourceHealth-pictures.com Cannot bind live tissue-keratinocytes/epithelium Cervical Cancer Type16,18,31,33 CIN(dyslasia)1->l->->Carcinoma in Situ Pap Smear Vaccine-against 16, 18

Circular dsDNA Over 50 strains Warts-skin, larynx, cervix, mucosa • Cannot bind live tissue- keratinocytes/epithelium Cervical Cancer • Type 16, 18, 31, 33 • CIN(dyslasia) I -> II -> III -> Carcinoma in Situ Pap Smear Vaccine- against 16, 18 Human Papilloma Virus