复旦大学：《医学微生物学 Medical Microbiology（MBBS）》课程讲义_理论课_Lecture1-Introducation to Medical Microbiology

Introduction to Medical Microbiology DiQu(瞿涤) MOH&MOE Key Lab of Medical Molecular Virology School of Basic Medical sciences Shanghai Medical College of Fudan University 复旦大学上海医学院分子病毒学 教育部/卫生部重点实验室 e|:54237524 dqu@shmu.edu.cn Chapter 1, 3

Introduction to Medical Microbiology Di Qu (瞿涤) MOH&MOE Key Lab of Medical Molecular Virology School of Basic Medical Sciences Shanghai Medical College of Fudan University 复旦大学上海医学院分子病毒学 教育部/卫生部重点实验室 Tel：54237524 dqu@shmu.edu.cn Chapter 1, 3

WHAT IS MICROBIOLOGY? WHAT IS MEDICAL MICROBIOLOGY? WHO STUDIES MEDICAL MICROBIOLOGY? · WHY DO WE STUDY? WHERE DO WE STUDY T? WHAT KNOWLEDGE WILL A STUDENT GAIN FROM THIS COURSE? HOW DO WE STUDY T? Textbook: Jawetz et al. Medical Microbiology 26th ed

• WHAT IS MICROBIOLOGY? • WHAT IS MEDICAL MICROBIOLOGY? • WHO STUDIES MEDICAL MICROBIOLOGY? • WHY DO WE STUDY IT? • WHERE DO WE STUDY IT? • WHAT KNOWLEDGE WILL A STUDENT GAIN FROM THIS COURSE? • HOW DO WE STUDY IT? Textbook: Jawetz et al. Medical Microbiology 26th ed

How to use the textbook it is not a easy book for beginner Attending the lectures, and on time Follow the lecture notes and keywords, read the textbook, and add more information to you notebook Pay attention to the summary or objectives in the end of each chapter, and go through the review questions If there any questions, just ask ou may catch"me in the lab after 4: 00 pm at weekday or weekendsmorning(54237524);dqu@shmu.edu.cn Homework: at the end of lecture ppt or on elearning Students: hand out on elearning in 2 weeks after lecture (deadline set on the elearning), email not acceptable Teacher: Feedback in 2 weeks(after the deadline for handing the homework)

How to use the textbook, it is not a easy book for beginner. Attending the lectures, and on time! Follow the lecture notes and keywords, read the textbook, and add more information to you notebook; Pay attention to the summary or objectives in the end of each chapter, and go through the review questions If there any questions, just ask; You may “catch” me in the lab after 4:00 pm at weekday or weekends morning (54237524) ; dqu@shmu.edu.cn Homework: at the end of lecture ppt. or on elearning Students: hand out on elearning in 2 weeks after lecture (deadline set on the elearning), email not acceptable Teacher: Feedback in 2 weeks (after the deadline for handing the homework) 3

Key Words Medical microbiology PROKARYOTES Eubacteria Bacteria Mycoplasma, Chlamydia, Spirochetes, Rickettsia, Actinomycetes ARCHAEA EUKARYOTES: Fungi NOT CELL Virus Prion

Key Words Medical microbiology PROKARYOTES  Eubacteria : Bacteria Mycoplasma, Chlamydia, Spirochetes, Rickettsia, Actinomycetes  ARCHAEA EUKARYOTES: Fungi NOT CELL  Virus  Prion

Micro-organisms(or microbes for short)affect every aspect of life on Earth can be friend or foe In all environments Many beneficial aspects Related to life processes (food web, nutrient cycling. . Only a minority are pathogenic, majority are completely harmless Most of our problems are caused by microbes We couldn't live without them, but they could ive without us

Micro-organisms (or microbes for short) affect every aspect of life on Earth can be friend or foe – In all environments – Many beneficial aspects – Related to life processes (food web, nutrient cycling…) – Only a minority are pathogenic， majority are completely harmless – Most of our problems are caused by microbes We couldn’t live without them, but they could live without us

Microorganisms Microorganisms Higher Organisms Environment

We are not alone 5 httppinter 2 est. com/as wimm/micro biome Healthy Soil Microbes, Healthy People

http://pinter est.com/as wimm/micro biome/ We are not alone The Human Microbiome project: -DIVERSE Healthy Soil Microbes, Healthy People

Microorganisms can be friend or foe Microbes interacting with hosts Microbes influence the evolution of http://pinterest.com/aswimm/microbiome/ hosts

Microorganisms can be friend or foe Microbes influence the evolution of hosts Microbes interacting with hosts http://pinterest.com/aswimm/microbiome/

Microbes and humans Very few microbes are always pathogenic Many microbes are potentially pathogenic Most microbes are never pathogenIC

Microbes and humans Very few microbes are always pathogenic Many microbes are potentially pathogenic Most microbes are never pathogenic

Mutualism Pathogenic- Commensal- Symbiotic 共存 共生 Driving forces for coevolution of bacterial-host relationship bacterial genetic diversity capacity for rapid growth high population density Commensalism and symbiosis are presented as part of a continuum, distinguished by the identification of specific benefits derived by one or both members of a host-bacterial partnership

Commensalism and symbiosis are presented as part of a continuum, distinguished by the identification of specific benefits derived by one or both members of a host-bacterial partnership. 共存 共生