复旦大学：《有机化学实验 Organic chemistry lab》课程教学资源（实验讲义）Synthesis of 1-bromobutane

E Organic Chemistry Experiment Synthesis of 1-bromobutane Chemistry teaching experiment center of fudan university

Synthesis of 1-bromobutane Organic Chemistry Experiment Chemistry teaching experiment center of Fudan university

迫套 Experimental purpose 1. Learn how to install gas absorption device 2. Master the method of extracting, washing and separating liquid with a separating funnel 3. Master the method of drying liquid organic compounds with desiccant 4. Synthesis of 1-bromobutane

Experimental purpose 1. Learn how to install gas absorption device 2. Master the method of extracting, washing and separating liquid with a separating funnel 3. Master the method of drying liquid organic compounds with desiccant 4. Synthesis of 1-bromobutane

E experimental background information 1-Bromobutane is a chemical with the formula C,hoBr Colorless transparent liquid, insoluble in water, slightly soluble in carbon tetrachloride. soluble in chloroform mixed soluble in ethanol. ether. acetone. It can be used as alkylation agent, solvent, rare element extraction agent and for organic synthesis

experimental background information 1-Bromobutane is a chemical with the formula C4H9Br. Colorless transparent liquid, insoluble in water, slightly soluble in carbon tetrachloride, soluble in chloroform, mixed soluble in ethanol, ether, acetone. It can be used as alkylation agent, solvent, rare element extraction agent and for organic synthesis

月 Experiment principle NaBr SsOA HBr NaHSO CH3 CH, CH2 CH,OH CH3 CH, CH, CH2 Br H2O

Experiment principle

Experiment noun 1. Reflux Condensing 2. Gas absorption 3. Extraction and Washing 4. Simple distillation 5. Fine distillation

Experiment noun 1. Reflux Condensing 2. Gas Absorption 3. Extraction and Washing 4. Simple Distillation 5. Fine Distillation

月 experimental medicine Sodium bromide fw.89 Concentrated Sulfuric Acid fw98 d 1.84 n-Butyl Alcohol Fw74 12 bp 117.7 C do.810 Ethanol FW4607 bp 783C d0789 Sodium bicarbonate fw. 01 Calcium Chloride Anhydrous Fw11098

experimental medicine Sodium Bromide FW 102.89 Concentrated Sulfuric Acid FW 98 d 1.84 n-Butyl Alcohol FW 74.12 bp 117.7 ℃ d 0.810 Ethanol FW 46.07 bp 78.3℃ d 0.789 Sodium Bicarbonate FW 84.01 Calcium Chloride Anhydrous FW110.98

9695 Experimental content. reflux, gas absorption device reflux. gas absorption device reflux. gas absorption device

Experimental content. reflux, gas absorption device reflux, gas absorption device reflux, gas absorption device

Experiment content crude distillation crude distillation cru distillation

Experiment content. crude distillation crude distillation crude distillation

Experimental content extraction, fine distillation extraction fine distillation fine distillation

Experimental content. extraction, fine distillation extraction fine distillation fine distillation

Experimental procedure 1. Reflux reaction 10 ml of water. 10 mL of concentrated sulfuric acid. 8 mL of n-butanol and 1.5 g of sodium bromide, two zeolites were added to a 100 mL round bottom flask and reflux for o5 h 2. Simple Distillation Replace it with a distillation unit. Until the distillate is free of oil droplets or clarified 3. Extraction and drying The crude distillation products were washed with 10 mL of water and 10 mL of concentrated sulfuric acid and then washed with water sodium dicarbonate aqueous solution and water sequentially The calcium chloride anhydrous was added 4. Fine distillation The dried product is filtered into a dry round bottom flask for fine distillation. 3 Fractions of 99-103.C were collected, weighed and yield calculated.o

Experimental procedure 1. Reflux reaction 10 mL of water, 10 mL of concentrated sulfuric acid, 8 mL of n-butanol and 11.5 g of sodium bromide, two zeolites were added to a 100 mL round￾bottom flask and reflux for 0.5 h. 2. Simple Distillation Replace it with a distillation unit. Until the distillate is free of oil droplets or clarified. 3. Extraction and drying The crude distillation products were washed with 10 mL of water and 10 mL of concentrated sulfuric acid, and then washed with water, sodium dicarbonate aqueous solution and water sequentially. The calcium chloride anhydrous was added. 4. Fine Distillation The dried product is filtered into a dry round bottom flask for fine distillation. Fractions of 99~103℃ were collected, weighed and yield calculated