复旦大学：《儿科学》课程教学资源（PPT课件讲稿）第一讲 小儿风湿性疾病-徐虹

Rheumatoid disease in children 小儿风湿性疾病 Childrens Hospital of Fudan University Xu Hong hxu ashmu. edu.cn

Rheumatoid Disease in Children 小儿风湿性疾病 Children’s Hospital of Fudan University Xu Hong hxu@shmu.edu.cn

Rheumatoid disease Connective tissue diseases (包含有120种与关节、骨骼、肌肉等相关的疾病) 过敏性紫癜( anaphylactoid purpura) 类风湿性关节炎(JRA) SLE (systemic lupus erythematosis) 皮肌炎( dermatomyositis) 硬皮病( scleroderma) 风湿热( rheumatic fever) 川崎病( Kawasaki disease

Rheumatoid Disease Connective tissue diseases （包含有120种与关节、骨骼、肌肉等相关的疾病） 过敏性紫癜（anaphylactoid purpura） 类风湿性关节炎（JRA） SLE（systemic lupus erythematosis） 皮肌炎（dermatomyositis） 硬皮病（scleroderma） 风湿热（rheumatic fever） 川崎病 (Kawasaki disease)

Rheumatoid disease in children TThe most common diseases Juvenile rheumatiod arthritis Henoch-Schonlein purpura Kawasaki disease MUcocutaneous Lymph Node syndrome, MCLS Rheumatic fever

Rheumatoid Disease in Children The most common diseases： • Juvenile Rheumatiod Arthritis • Henoch-Schonlein purpura • Kawasaki Disease (Mucocutaneous Lymph Node Syndrome, MCLS) • Rheumatic Fever

冠状动脉造影 Coronary angiogram Normal Coronary Artery LAO

冠状动脉造影 Coronary angiogram

Henoch-Schonlein purpura Alternative names: Anaphylactoid purpura Ⅴ ascular purpura

Henoch-Schonlein purpura Alternative names: •Anaphylactoid purpura • Vascular purpura

Definition Henoch-schonlein purpura is a disease that has the svmptoms purple spots on the skin Joint pain gastrointestinal symptoms glomerulonephritis (a type of kidney disorder)

Definition Henoch-Schonlein purpura is a disease that has the symptoms • purple spots on the skin • joint pain • gastrointestinal symptoms • glomerulonephritis • (a type of kidney disorder)

History story Schonlein's Purpura Henoch's Purpura (In 1837, Johan Schonlein Later, his student, Eduard Henoch) the skin and ioints are affected purpura spots on the skin and acute abdominal but the gastrointestinal problems tract is not not affected by joint dis sease

History story • Schonlein's Purpura ( In 1837, Johan Schonlein ) the skin and joints are affected but the gastrointestinal tract is not • Henoch's Purpura (Later, his student, Eduard Henoch ) purpura spots on the skin and acute abdominal problems not affected by joint disease

General conditions a type of hypersen sitivity vasculitis and inflammatory response within the blood vessel It is caused by an abnormal response of the immune system The exact cause for this disorder is unknown The syndrome is usually seen in children, but people of any age may be affected It is more common in boys than in girls Many people with Henoch-Schonlein purpura had an upper respiratory illness in the previous weeks

General conditions • a type of hypersensitivity vasculitis and inflammatory response within the blood vessel • It is caused by an abnormal response of the immune system • The exact cause for this disorder is unknown. • The syndrome is usually seen in children, but people of any age may be affected • It is more common in boys than in girls • Many people with Henoch-Schonlein purpura had an upper respiratory illness in the previous weeks

Causes and pathogenesis An inflammatory disease of the small blood vessels(capillaries usually a self-limited disease It is the most common form of childhood vascular inflammation(vasculitis)and results in inflammatory changes in small blood vessels

Causes and pathogenesis • An inflammatory disease of the small blood vessels (capillaries) • usually a self-limited disease • It is the most common form of childhood vascular inflammation (vasculitis) and results in inflammatory changes in small blood vessels