脑动静脉畸形（CEREBRAL ARTERIOVENOUS MALFORMATIONS）

AVM: a TLA for the Cns CEREBRAL ARTERIOVENOUS MALFORMATIONS

CEREBRAL ARTERIOVENOUS MALFORMATIONS AVM: a TLA for the CNS

Incidence 0. 52% at autopsy Slight male preponderance(1.09 to 1.94) Congenital lesions(although rarely familial

Incidence 0.52% at autopsy Slight male preponderance (1.09 to 1.94) Congenital lesions (although rarely familial)

Embryology First half of third week of gestation epiblastic cells migrate to form mesoderm mesodermal cells differentiate to arterial and venous vessels on the sur face of the embryonic nervous system

Embryology First half of third week of gestation epiblastic cells migrate to form mesoderm mesodermal cells differentiate to arterial and venous vessels on the surface of the embryonic nervous system

Embryology First half of third week of gestation epiblastic cells migrate to form mesoderm mesodermal cells differentaite to arterial and venous vessel on the surface of the embryonic nervous system Seventh gestational week vessels sprout branches penetrate developing brain reach the gray-white interface, either loop back to pial surface or traverse entire neural tube, thus epicerebral transcerebral circn eventually connect arterial and venous systems by around the twelfth week

Embryology First half of third week of gestation epiblastic cells migrate to form mesoderm mesodermal cells differentaite to arterial and venous vessels on the surface of the embryonic nervous system Seventh gestational week vessels sprout branches & penetrate developing brain reach the gray-white interface, either loop back to pial surface or traverse entire neural tube, thus epicerebral & transcerebral circ'n eventually connect arterial and venous systems by around the twelfth week

Pathology pathophysiology absence of normal capillary system

Pathology & Pathophysiology absence of normal capillary system

Pathology pathophysiology absence of normal capillary system usual function displaced

Pathology & Pathophysiology absence of normal capillary system usual function displaced

Pathology pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth

Pathology & Pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth

Pathology pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth vessels change with time may develop aneurysms

Pathology & Pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth vessels change with time may develop aneurysms

Pathology pathophysiology absence of normal parenchymal changes capillary system within and around the usual function displaced lesion asymptomatic at birth vessels change with time may develop aneurysms

parenchymal changes within and around the lesion Pathology & Pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth vessels change with time may develop aneurysms

Pathology pathophysiology absence of normal parenchymal changes capillary system within and around the usual function displaced lesion asymptomatic at birth site frequency is vessels change with proportional to brain time volume may develop aneurysms

parenchymal changes within and around the lesion site frequency is proportional to brain volume Pathology & Pathophysiology absence of normal capillary system usual function displaced asymptomatic at birth vessels change with time may develop aneurysms