香港大学医学院：局部血液循环紊乱（PPT讲稿）The disorder of local circulation

The disorder of local circulation Dr Philip s L Beh Email philipbeh@pathology. hku. hk

The disorder of local circulation Dr. Philip S.L. Beh Email: philipbeh@pathology.hku.hk

Lecture outline Overview and revisit basic concepts Circulatory system Structure of blood vessels Components of blood Oedema Generalised ocal Effects on Brain and Lungs Hemostasis- Normal physiological response Thrombosis - Abnormal pathological response Other forms of obstruction Infarction Abnormal pathological outcome

Lecture Outline ➢ Overview and revisit basic concepts ⚫ Circulatory system ⚫ Structure of blood vessels ⚫ Components of blood ➢ Oedema ⚫ Generalised ⚫ Local ⚫ Effects on Brain and Lungs ➢ Hemostasis – Normal physiological response ➢ Thrombosis – Abnormal pathological response ➢ Other forms of obstruction ➢ Infarction – Abnormal pathological outcome

Overview and Revisit Circulatory System Structure of blood vessels Components of blood

Overview and Revisit ➢ Circulatory System ➢ Structure of blood vessels ➢ Components of Blood

Circulatory system >Heart- Pump Blood Vessels-Pipes ° Artery,ven, Capillary Lymphatics- Drainage pipes

Circulatory System ➢ Heart – Pump ➢ Blood Vessels – Pipes ⚫ Artery, Vein, Capillary ➢ Lymphatics – Drainage pipes

Properties of circulatory system > Ensure smooth and adequate flow of blood Delivers nutrients and oxygen Removes waste and carbon dioxide

Properties of circulatory system ➢ Ensure smooth and adequate flow of blood. ➢ Delivers nutrients and oxygen ➢ Removes waste and carbon dioxide

Properties of arteries Aorta Comes off the heart Sustains high blood pressures Elastic but rigid wa‖l Arteries ° Lower blood pressures Often have muscular wall and can contract

Properties of arteries ➢ Aorta ⚫ Comes off the heart ⚫ Sustains high blood pressures ⚫ Elastic but rigid wall ➢ Arteries ⚫ Lower blood pressures ⚫ Often have muscular wall and can contract

Structure of artery Connective r Smooth muscle tissue tissue ARTERY Endothelial tissue akenfromwww.sirinet.net/igjohnso/circulationhtml

Structure of artery Taken from www.sirinet.net/~jgjohnso/ circulation.html

Properties of veins y Thin wall Some have valves to prevent back-flow of blood Weak ability to contract even if there are muscle fibers in the wall Dependant on" pumping action of surrounding muscles-particularly of the limbs

Properties of veins ➢ Thin wall ➢ Some have valves to prevent back-flow of blood ➢ Weak ability to contract even if there are muscle fibers in the wall. ➢ Dependant on “pumping action of surrounding muscles – particularly of the limbs

Structure of vein Capillary Epithelial tissue Epithelial Valve tissue Epithelial tissue Smooth muscle Smooth muscle Connective Connective tissue tissue Arteriole Artery Vein Takenfromwww.sirinet.net/-jgjohnso/circulationhtml

Structure of vein Taken from www.sirinet.net/~jgjohnso/ circulation.html

Properties of capillary bed Very thin wall often only one cell-thick and can change to allow blood to pass through into the interstitial space

Properties of capillary bed ➢ Very thin wall often only one cell-thick and can change to allow blood to pass through into the interstitial space