中枢神经系统 CNS

CNS

CNS

Classical Disease Patterns Degenerative Inflammatory Neoplastic o Blood

Classical Disease Patterns • Degenerative •Inflammatory • Neoplastic • Blood

CNS ● Norma -Neurons Glia Astrocytes Oligodendrocytes Ependymal Cells Microglia Pathology (13 Questions

CNS • Normal –Neurons –Glia • Astrocytes • Oligodendrocytes • Ependymal Cells • Microglia • Pathology (13 Questions)

CNS DEGENERATIVE DISEASES CORTEX (dementias) BASAL GANGLIA and brain STEM (parkinsonian) SPINOCEREBELLAR(ataxias MOTOR NEURONS(muscle atrophy)

CNS DEGENERATIVE DISEASES • CORTEX (dementias) • BASAL GANGLIA and BRAIN STEM (parkinsonian) • SPINOCEREBELLAR (ataxias) • MOTOR NEURONS (muscle atrophy)

CNS DEGENERATIVE DISEASES CORTEX(dementias) ALZHEIMER DISEASE Frontotemporal Pick Disease also primarily frontal) Progressive Supranuclear Palsy(PSP) -CorticoBasal Degeneration(CBD) Vascular Dementias(MID)

CNS DEGENERATIVE DISEASES • CORTEX (dementias) –ALZHEIMER DISEASE –Frontotemporal –Pick Disease (also primarily frontal) –Progressive Supranuclear Palsy (PSP) –CorticoBasal Degeneration (CBD) –Vascular Dementias (MID)

ALZHEIMER DISEASE Commonest cause of dementias majority) Sporadic, 5-10% familial CORTICAL (grey matter) ATROPHY NEURITIC PLAQUESX lextraneuronal NEUROFIBRILLARY TANGLES (intraneuronal) AMYLOID!!!(Le,,"BETA amyloid)

ALZHEIMER DISEASE • Commonest cause of dementias (majority) • Sporadic, 5-10% familial • CORTICAL (grey matter) ATROPHY • NEURITIC PLAQUES* (extraneuronal) • NEUROFIBRILLARY TANGLES (intraneuronal) • AMYLOID!!! (i.e., “BETA” amyloid)

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导5 Neuritic plaques Neuritic plaques, stained with anti- beta amyloid immunostain

Neuritic plaques Neuritic plaques, stained with anti- beta amyloid immunostain