山东大学基础医学院：《病理生理学 Pathophysiology》课程PPT教学课件（7年制）05 fever 发热

Fever

Fever

38℃ 38.0℃ 378℃ 38.0 37:6c 37.5°c 37℃ 36C 36.4 36℃ 359℃ 35.8035.8℃ 35℃ 伯 34℃ 0~2岁3-10岁165岁0e65岁

Normal Axillary temperature 36-37.0C Sublingual temperature 36.7-377C rectal temperature 369-379C

Normal Axillary temperature 36~37 .0 C Sublingual temperature 36.7~37.7 C rectal temperature 36.9~37.9 C

一、 Concept pyrogen set point of the thermoregulatory center I bod temperature

一、 Concept pyrogen set point of the thermoregulatory center body temperature

sport ★★★★ physiological pregnancy luteal phase T hyperthermia pathological ( set point±) fever

 sport  physiological T pregnancy  luteal phase  hyperthermia  pathological T （set point ±）  fever T

*Hyperthermia thermogenesis thermolysis dysfunction of thermoregulatory center

Hyperthermia : thermogenesis thermolysis dysfunction of thermoregulatory center

二、 Causes and pathogenesis of fever Pyrogen and activator of fever Activator: the substance can activate the cells that can produce the pyrogen. pyrogen: the substance can cause fever

二、 Causes and pathogenesis of fever Pyrogen and activator of fever Activator : the substance can activate the cells that can produce the pyrogen. pyrogen: the substance can cause fever

Activators of fever microbe: G LPS ET G peptidoglycan vIrus: enveloped virus 1. Extragenous particle: transfuse response pyrogen 2. internal production immune complexes etiocholanolone

Activators of fever microbe: G- LPS, ET G+ peptidoglycan virus: enveloped virus particle:transfuse response 2. internal production immune complexes etiocholanolone 1. Extragenou pyrogen

Endogenou pyrogen(EP) interleukin-1(IL-1): MC, fibroblast IL-6: T, B lymphocyte, tumor cell TNE TNFa DM TNFB (lymphotoxin)active T interferon (IFN): T lymphocyte

Endogenou pyrogen(EP) interleukin-1(IL-1) :MC,fibroblast IL-6:T,B lymphocyte,tumor cell TNF : TNFα Mφ TNFβ (lymphotoxin) active T interferon ( IFN ): T lymphocyte

1.0 IL=18 (200 ng/kg) 合 TINF-a (504gkg) 0.5 rTNF-a 的增 (500 ng/kg) rlL-1B(70℃)200ngkg) 0 30 60 120 150 180 Minutes 图12-2家兔静脉分别注射rI1B、rNF-a、rFN-a引起的发热反应