广州医科大学（广州医学院）：《病理学》课程教学资源（PPP课件，四，英文版）Disorders of hematopoietic and lymphoid systems

Disorders of hematopoietic and lymphoid systems Department ofpathology longjie

Disorders of hematopoietic and lymphoid systems Department of pathology longjie

Lymphoma淋巴瘤 Leukemia 白血病

Lymphoma 淋巴瘤 Leukemia 白血病

What is malignant lymphoma? Malignant Lymphoma 恶性淋巴瘤 Classification of ml

Malignant Lymphoma 恶性淋巴瘤 What is malignant lymphoma? Classification of ML

In this group of lympho-proliferative diseases, normal lymphoid tissue is replaced by abnormal cells of lymphoid origin forming solid malignant tumors of the lymph nodes Malignant lymphoma(ML)

Malignant lymphoma (ML) In this group of lympho-proliferative diseases, normal lymphoid tissue is replaced by abnormal cells of lymphoid origin forming solid malignant tumors of the lymph nodes

Classiffication of ml Hodgkin's lymphoma, HL Non- Hodgkin's lymphoma, NHL

Hodgkin’s lymphoma, HL Classification of ML Non-Hodgkin’s lymphoma, NHL

Hodgkins lymphoma 1. Presence of the distinctive neoplastic R-s cells and non-neoplastic cells usually greatly outnumber the tumor cells 2. Studies show that it is a tumor come of b lymphomacytes

Hodgkin’s lymphoma 1. Presence of the distinctive neoplastic R-S cells and non-neoplastic cells usually greatly outmumber the tumor cells. 2. Studies show that it is a tumor come of B lymphomacytes

Pato0 gical change of乩L Generral features Grossly Microscopically Classification Clinical course

Pathological change of HL Generral features Grossly Microscopically Classification Clinical course

Heneral features 1. a painless enlargenment of the lymph nodes 2. More often in upper half of the body cervical axillary, para-aortic) 3. Initially localized to a single peripheral lymph node region but orderly spread by contiguity nodes 4. Extranodal involvement uncommon

1. a painless enlargenment of the lymph nodes. General features 3. Initially localized to a single peripheral lymph node region but orderly spread by contiguity nodes. 4. Extranodal involvement uncommon. 2.More often in upper half of the body (cervical, axillary, para-aortic)

Grossly 1. The affected lymph node are enlarged, with a smooth surface, and the lymph node capsule is rarely breached 2. Lymph nodes conglutinate to be a fixed, nodular mass 3. Cut surface: white-gray fishy, yellowish necrosis

Grossly 1. The affected lymph node are enlarged, with a smooth surface, and the lymph node capsule is rarely breached . 2. Lymph nodes conglutinate to be a fixed, nodular mass. 3. Cut surface: white- gray ,fishy, yellowish necrosis

Microscopically Normal construction of lymph nodes were distroied 2. Characterized morphologically by the presence of distinctive neoplastic giant cells called Reed- Sternberg(Rs)cells; 3, The rs cells admixed with a variable infiltrate of reactive, nonmalignant inflammatory cells;

Microscopically 1. Normal construction of lymph nodes were distroied. 2. Characterized morphologically by the presence of distinctive neoplastic giant cells called Reed￾Sternberg (RS) cells; 3. The RS cells admixed with a variable infiltrate of reactive, nonmalignant inflammatory cells;