上海交通大学：《病理生理学》课程教学资源（PPT课件讲稿）第八章 缺氧

缺氧 (hypoxia)

缺 氧 (hypoxia)

Hypoxia 、概念( Concept Hypoxia] 当组织的氧供应不足,或组织利用氧障碍时,导致机体功能、 代谢和形态结构的异常变化,甚至危及生命的病理状态。 Hypoxia is referred to a pathological process in which oxygen supply to tissues or organs is inadequate to meet the demand of cells, or there is adequate delivery to tissue but the tissue cells cannot make use of oxygen, leading to changes in functions metabolisms and structures of cells and tissues of the body

【Hypoxia】 当组织的氧供应不足，或组织利用氧障碍时，导致机体功能、 代谢和形态结构的异常变化，甚至危及生命的病理状态。 一、概念（Concept） Hypoxia is referred to a pathological process in which oxygen supply to tissues or organs is inadequate to meet the demand of cells, or there is adequate delivery to tissue but the tissue cells cannot make use of oxygen, leading to changes in functions,metabolisms and structures of cells and tissues of the body. Hypoxia

Hypoxia Hypoxemia】 指动脉血氧含量明显降低引起对组织供氧不足。 Oxygen content of the arterial blood is lower than normal that is called hypoxemia

【Hypoxemia】 指动脉血氧含量明显降低引起对组织供氧不足。 Oxygen content of the arterial blood is lower than normal that is called hypoxemia. Hypoxia

Hypoxia 二、血氧检测指标 (Parameters of blood oxygen)

二、血氧检测指标 （Parameters of blood oxygen） Hypoxia

Hypoxia 1氧分压( Partial pressure of oxygen,PO2 2血氧容量( Oxygen binding capacity, CO2max 3氧含量( Oxygen content,CO2 4动静脉氧差(AO2 5>氧饱和度( Oxygen saturation,SoO2 6 50

1 氧分压（Partial pressure of oxygen, PO2） Hypoxia 2 血氧容量（Oxygen binding capacity, CO2max） 3 氧含量（Oxygen content, CO2） 4 动-静脉氧差（A-VdO2） 5 氧饱和度（Oxygen saturation, SO2） 6 P50

Hypoxia aPartial pressure of oXygen,( PO2) Definiens】 PO2 is the pressure or tension caused by oxygen physically Dissolved in the blood 【 norma|vaue】 Pao2: 13 3kPa(100mmHg): PvO2: 5.32kPa(40mmHg) Influence】 吸入空气的p○2、肺的呼吸功能、静脉血掺杂程度。 Significance】 PaO2高低直接影响动脉血氧含量(O2与Hb结合)、血氧饱和度、 氧弥散速度

■Partial pressure of oxygen, ( PO2 ) 【Definiens】 PO2 is the pressure or tension caused by oxygen physically Dissolved in the blood. Hypoxia 【Significance】 PaO2高低直接影响动脉血氧含量（O2与Hb结合）、血氧饱和度、 氧弥散速度。 【Normal value】 PaO2 : 13.3kPa(100mmHg)；PvO2 : 5.32kPa(40mmHg)。 【Influence】 吸入空气的pO2、肺的呼吸功能、静脉血掺杂程度

Hypoxia oXygen binding capacity, CO2max Definiens】 CO, max Is the maximum amount of oxygen combined by Hb in 100ml blood under fully saturated condition in which the PO2 is 150mmHg, PCO2 40mmHg, and the tem perature is 38C. Normal value】 CO2 max: 8.92mmol/L (1.34ml/gx 15gHb% Influence】 =20m%)。 Hb的质(Hb结合氧的能力)和量 Significance】 血氧容量大小反映血液携氧能力( Oxygen-carrying capacity)

■Oxygen binding capacity, CO2max 【Definiens】 CO2max Is the maximum amount of oxygen combined by Hb in 100ml blood under fully saturated condition in which the PO2 is 150mmHg, PCO2 40mmHg, and the temperature is 38℃. 【Significance】 血氧容量大小反映血液携氧能力(Oxygen-carrying capacity)。 【Normal value】 CO2max: 8.92mmol/L (1.34ml/g×15gHb% 【Influence】 =20ml%)。 Hb的质（Hb结合氧的能力）和量 Hypoxia

Hypoxia oXYgen content( Co2) Definiens】 The total amount of oxygen contained actually in 100 ml blood sample, including the part combined with Hb and the part physically dissolved in plasma norma|vaue】 caO2约847mmoM(193m%);CO2为535mmoL(14m%) Significance】 提示血液实际供氧水平。 PFcc co Influence】 PaO2&cO2max。 心空令

■Oxygen content ( CO2 ) 【Definiens】 The total amount of oxygen contained actually in 100 ml blood sample, including the part combined with Hb and the part physically dissolved in plasma. 【Significance】 提示血液实际供氧水平。 【Normal value】 CaO2约8.47mmol/L(19.3ml%)；CvO2为5.35mmol/L(14ml%)。 【Influence】 PaO2 & CO2max。 Hypoxia

Hypoxia A-VdO2 Definiens】 The difference value is between arterial and venous blood oxygen content Significance】 反映100m血液流经组织时所提供的氧量或组织细胞利用氧量 【 Norma|vaue】 AvdO2通常为2.23~357mmoL(⑤5m%~8m%) 19ml/dl 14m/dl A O2,O 5mld

19ml/dl 14ml/dl 5ml/dl A O2 O2 O2 O2 O2 O V 2 ■A-VdO2 【Definiens】 The difference value is between arterial and venous blood oxygen content. 【Significance】 反映100ml血液流经组织时所提供的氧量或组织细胞利用氧量。 【Normal value】 A-VdO2通常为2. 23～3.57mmol/L(5ml%～8ml%)。 Hypoxia

Hypoxia oXygen saturation, sO2 【 Definiens】 The degree of connected 1g Hb to oxygen SO2%=CO2-O2 dissolved physically in plasma/CO2max (Normal value) P sao2:93%~98%; p↑}左移 80}温度↓ P SvO2:70%~75% 右移{pH↓ 蛋 Significance) 温度 饱 反映Hb与氧的结合程度。° Influence】 0 Pao2 Po,27538.0107133160kPa 0 4 100 120 mmh Factors affecting oxygen dissociation curve

■Oxygen saturation, SO2 【Definiens】 The degree of connected 1g Hb to oxygen SO2% = CO2 – O2 dissolved physically in plasma/ CO2max 【Normal value】 SaO2：93%～98%； SvO2：70%～75%。 【Significance】 反映Hb与氧的结合程度。 【Influence】 PaO2。 Factors affecting oxygen dissociation curve Hypoxia