扬州大学：《生物化学 Biochemistry》课程教学课件（讲稿）01 The chemical Basis of Life

Essential BiochemistryThird EditionCharlotte W.Pratt and Kathleen Cornely

Essential Biochemistry Third Edition Charlotte W. Pratt and Kathleen Cornely

Chapter 1: The chemical Basis of Life·Introduction to Biochemistry: Introduce some basic concepts of biochemistry:See itsrelationtoothersciences·Seeitssignificanceandrelevance

Chapter 1: The chemical Basis of Life • Introduction to Biochemistry • Introduce some basic concepts of biochemistry • See its relation to other sciences • See its significance and relevance

Biochemistry involves the study of 4 types of molecules:Biochemistry is a science that seeks to understand and explain lifeatthemolecularlevel? We will consider more of the details as we proceed? Four types of molecules you will see throughout the courseNucleic AcidsProteilBiochemistryThescientificdisciplinethatseekstoexplailifeatthemolecularlevelCarbohydratesGlucose

Biochemistry involves the study of 4 types of molecules • Biochemistry is a science that seeks to understand and explain life at the molecular level • We will consider more of the details as we proceed • Four types of molecules you will see throughout the course

The textbook is divided into 4 basic sectionsSectionI:Chapter 1 (a brief introduction and review)Chapter 2 (water and its properties)All living systems operate in an aqueous environmentUnderstanding the properties of water is crucial to understandhowmolecules behave inthat environment.·Section Il: Chapter 3 to Chapter 11 (molecular structure and function)the most fundamental biochemistry:the direct relationship betweenthe structureof biological molecule/systemand itsfunction-Understandingfunctionenablesusfitintothelargercontextofthecell/organism

The textbook is divided into 4 basic sections. • Section Ⅰ: Chapter 1 (a brief introduction and review) Chapter 2 (water and its properties) All living systems operate in an aqueous environment. Understanding the properties of water is crucial to understand how molecules behave in that environment. • Section Ⅱ: Chapter 3 to Chapter 11 (molecular structure and function) the most fundamental biochemistry: the direct relationship between the structure of biological molecule/system and its function —— Understanding function enables us fit into the larger context of the cell/organism

The textbook is divided into 4 basic sections·SectionI1l:Chapter12toChapter19the transformation of matter and energy (metabolism)·Section IV:chapter 20 to chapter 22, as well as chapter 3the management of genetic informationA building under construction:a symbol for basic foundation (principals)It is build in a step by step fashion

The textbook is divided into 4 basic sections. • Section Ⅲ：Chapter 12 to Chapter 19 the transformation of matter and energy (metabolism) • Section Ⅳ：chapter 20 to chapter 22, as well as chapter 3 the management of genetic information A building under construction: a symbol for basic foundation (principals) It is build in a step by step fashion

A new science·Biochemistry is ayoung science.Most of the information included in this bookhas been uncovered inthe last 50 years (go through much further than the last 50 years).KnowledgeisaccumulatedGainabetterunderstandingof basicbiological systems and howtheyfunction·Researchtechniqueshavebeendeveloped-betterunderstandthese systemsTechniques growin process.>Science & methods used to elucidate and study science

A new science • Biochemistry is a young science • Most of the information included in this book has been uncovered in the last 50 years (go through much further than the last 50 years). • Gain a better understanding of basic biological systems and how they function • Research techniques have been developed - better understand these systems Science & methods used to elucidate and study science Techniques grow in process. Knowledge is accumulated

ThesignificanceofBiochemistrythe capacityto explain living systems atthemolecularlevel: A thorough understanding of each molecule's physical structure andchemical reactivity helps to lead to an understanding of how moleculescooperate and combine to form large functional units and, ultimately,theintactorganismOrganelleOrganMoleculeOrganism(function)Large cell

The significance of Biochemistry — the capacity to explain living systems at the molecular level • A thorough understanding of each molecule’s physical structure and chemical reactivity helps to lead to an understanding of how molecules cooperate and combine to form large functional units and, ultimately, the intact organism. Molecule Organelle Organ (function) Large cell Organism

Biochemical“Language"? Need unambiguous way to refer to certain molecules and pathways.Useofconsistentterminology? Need unambiguous way to illustrate moleculesIllustrate3-dimentional molecules in2D space[aelani:n]AlanineCOO-H-CCH3NH(a)(b)Structural formulaSpace-filling model(atoms&bonds)Ball-and-stickmodel(size)(whichatomsandwhere)Conveys:atoms present, bonds connecting them, size, how they are arranged in 3D space

Biochemical “Language” • Need unambiguous way to refer to certain molecules and pathways. • Use of consistent terminology • Need unambiguous way to illustrate molecules Illustrate 3-dimentional molecules in 2D space Alanine Conveys: atoms present, bonds connecting them, size, how they are arranged in 3D space ['æləniːn]

Biochemistryis...·Achemicalscience·Studyof structuresandtheirchemical interactions·Astudyinthermodynamics.TransformationofenergyintolivingmatterThese two aspects will be involved in almost every topic we will consider

Biochemistry is. • A chemical science • Study of structures and their chemical interactions • A study in thermodynamics • Transformation of energy into living matter These two aspects will be involved in almost every topic we will consider

RoleofBiochemistry·Unityofbiochemistry.Structures,mechanisms,and chemical processes shared by all organisms.E.coli.....human· Biochemical study elucidates the organizing principles of life inallitsdiverseforms·Biochemistry is ultimately concerned with the wonder of life itself

Role of Biochemistry • Unity of biochemistry • Structures, mechanisms, and chemical processes shared by all organisms • E.coli. human • Biochemical study elucidates the organizing principles of life in all its diverse forms • Biochemistry is ultimately concerned with the wonder of life itself