《生物化学》课程PPT教学课件（留学生）Chapter 10 Gluconeogenesis

BIOCHEMISTRYANDMOLECULARBIOLOGYChapter 10GluconeogenesisDepartment of Biochemistryand MolecularBiology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Chapter 10 Gluconeogenesis

BIOCHEMISTRYANDMOLECULARBIOLOGYOutlineOverviewReactions in GluconeogenesisThe characteristics and significanceGluconeogenesis from different substancesAdditionalcontentDepartment of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢ Overview ➢ Reactions in Gluconeogenesis ➢ The characteristics and significance ➢ Gluconeogenesis from different substances ➢ Additional content Outline

BIOCHEMISTRYANDMOLECULARBIOLOGYOutlineOverviewReactions in GluconeogenesisThe characteristics and significanceGluconeogenesis from different substancesAdditionalcontentDepartment of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢ Overview ➢ Reactions in Gluconeogenesis ➢ The characteristics and significance ➢ Gluconeogenesis from different substances ➢ Additional content Outline

BIOCHEMISTRYANDMOLECULARBIOLOGYGluconeogenesisGlucose is formed fromnprecursorssuchaslactate, pyruvate, glycerol, glucogenic amino Acid.Department of Biochemistryand MolecularBiology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Gluconeogenesis Glucose is formed from precursors such as lactate, pyruvate, glycerol, glucogenic amino Acid

BIOCHEMISTRYANDMOLECULARBIOLOGY·Glycerol(derived from the backbone of triacylglycerols)·a-ketoacids(derived from amino acid catabolism)Department of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY • Glycerol (derived from the backbone of triacylglycerols) •α-ketoacids (derived from amino acid catabolism)

XBIOCHEMISTRYANDMOLECULARBIOLOGYTheprocess of gluconeogenesis> The process of gluconeogenesis are mainlyreciprocal glycolysis.> Only three reaction do not reverse.Department of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY The process of gluconeogenesis ➢ The process of gluconeogenesis are mainly reciprocal glycolysis. ➢ Only three reaction do not reverse

BIOCHEMISTRYANDMOLECULARBIOLOGYOutlineOverviewReactions in GluconeogenesisThe characteristics and significanceGluconeogenesis from different substancesAdditionalcontentDepartment of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY ➢ Overview ➢ Reactions in Gluconeogenesis ➢ The characteristics and significance ➢ Gluconeogenesis from different substances ➢ Additional content Outline

GlucoseGlucose6-PGlucoseGlucose个Fructose6-P3LSFructose1,6-bis-PGlyceraldehyde3-PDihydroxy-acetone-p1个glycolysisgluconeo1,3-bis-Phosphoglycerategenesis1个3-Phosphoglycerate12-Phosphoglycerate1个Phosphoenolpyruvate+LactatePyruvateCOGPyruvatePyruvateOxaloacetate

Glucose Pyruvate glycolysis Glucose Pyruvate gluconeo genesis

BIOCHEMISTRYANDMOLECULARBIOLOGYReactionsinGlycolysis> Seven of the ten reactions of Glycolysis are reversible andare used in the synthesis of glucose from lactate or pyruvate.> However, three of the reactions are irreversible and mustbe circumvented by four alternate reactions that energeticallyfavor the synthesis of glucoseDepartment of Biochemistry and Molecular Biology,Medicine School

Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Reactions in Glycolysis ➢ Seven of the ten reactions of Glycolysis are reversible and are used in the synthesis of glucose from lactate or pyruvate. ➢ However, three of the reactions are irreversible and must be circumvented by four alternate reactions that energetically favor the synthesis of glucose

GlucoseGlucose6-PGlucoseGlucose个Fructose6-P3LSFructose1,6-bis-PGlyceraldehyde3-PDihydroxy-acetone-p1个glycolysisgluconeo1,3-bis-Phosphoglycerategenesis1个3-Phosphoglycerate12-Phosphoglycerate1个Phosphoenolpyruvate+LactatePyruvateCOGPyruvatePyruvateOxaloacetate

Glucose Pyruvate glycolysis Glucose Pyruvate gluconeo genesis