球菌 Coccus：化脓性球菌的放大：疾病和发病机制 Zooming in pyogenic coccus：disease and pathogenesis

3.30 3.30 Me Lectures: The pyogenic cocci D) Mo Lectures: The pyogenic cocci Wed Lectures: The pyogenic cocci(2) 4.1 Lectures: Enterobacteriaceae, Vibrios, Mycobacteria Wed helicobacter pylori, Corynebacterium(1) Lectures: Enterobacteriaceae, Vibrios, Mycobacteria 4.6 helicobacter pylori, Corynebacterium(1) Mon 4.6 Lab: Care and use of the microscope Mor Catre and tse ef the-fmereseer 4.8 Lectures: Enterobacteriaceae, Vibrios, Mycobacteria Lectures: Enterobacteriaceae, Vibrios, Mycobacteria Wed helicobacter pylori, Corynebacterium(2) Wed helicobacter pylori, Corynebacterium(2) 4.9 Lab: Care and use of the microscope Thur Thur Lab, Care and use or te croscope The labs in the next week are canceled. will be shifted to the following week bs will extend to 5.25 and 5.28

3.30 Mon Lectures: The pyogenic cocci (1) 4.1 Wed Lectures: The pyogenic cocci (2) 4.6 Mon Lectures: Enterobacteriaceae,Vibrios,Mycobacteria helicobacter pylori，Corynebacterium (1) Lab: Care and use of the microscope 4.8 Wed Lectures: Enterobacteriaceae,Vibrios,Mycobacteria helicobacter pylori，Corynebacterium (2) 4.9 Thur Lab: Care and use of the microscope 3.30 Mon Lectures: The pyogenic cocci 4.1 Wed Lectures: Enterobacteriaceae,Vibrios,Mycobacteria helicobacter pylori，Corynebacterium (1) 4.6 Mon Lab: Care and use of the microscope 4.8 Wed Lectures: Enterobacteriaceae,Vibrios,Mycobacteria helicobacter pylori，Corynebacterium (2) 4.9 Thur Lab: Care and use of the microscope The labs in the next week are canceled, will be shifted to the following week. Labs will extend to 5.25 and 5.28

Coccus Zooming in pyogenic coccus disease and pathogenesis

Coccus Zooming in pyogenic coccus: disease and pathogenesis

Pyogenic coccus Medically Important Bacteria Lacking Rigid cell wall Flexible cell walls (Spirochetes) Borrelia MycopLasma ureaplasma Simple unicellular Filamentous Actinomyces Nocardia Obligate intracellular Free-living parasite Chlamydia Coniella Ehrlichia Gram-positive Gram-negative

Pyogenic coccus

Pyogenic coccus Gram-positive Gram-negative Cocci Rods Cocci Nonenteric Enteric rods rods Enterococcus Bacillus Acinetobacter Bacterioides Peptostreptococcus CLostridium crayola Bartonella Campylobacter Staphylococcus Corynebacterium Neisseria Bordetella Enterobacter Streptococcus Erysipelothrix Escherichia Brucella Lactobacillus Francisella Fusobacterium Listeria Helicobacter hemophilus Propionibacterium Klebsiella PrevottetIn Pasteurella Proteus Pseudomonas Providencia Staphylococcal Pseudomonas Salmonella Serratia vibrio Yersinia

Pyogenic coccus

Major pathogenic species r Staphylococcus(the staphylococcus) o Staphylococcus aureus o Staphylococcus epidermidis o Staphylococcus saprophyticus r Streptococcus(the streptococcus o Streptococcus pyogenes o Streptococcus pneumoniae( the pneumococcus) r Neisseria(the neisseria) o Neisseria meningitidis( the meningococcus o Neisseria gonorrhoeae( the gonococcus)

Major pathogenic species Staphylococcus (the staphylococcus) Staphylococcus aureus Staphylococcus epidermidis Staphylococcus saprophyticus Streptococcus (the streptococcus) Streptococcus pyogenes Streptococcus pneumoniae (the pneumococcus) Neisseria (the neisseria) Neisseria meningitidis (the meningococcus) Neisseria gonorrhoeae (the gonococcus)

Staphylococcus aureus r Diseases r Pathogenesis o Roles of bacterial virulent factors r Diagnosis o Methods for bacteria classification r Treatment and prevention o Issues

Staphylococcus aureus Diseases Pathogenesis Roles of bacterial virulent factors Diagnosis Methods for bacteria classification Treatment and prevention Issues

Bacteria morphology r Staphylococcus grape-like irregular clusters r Streptococcus chains or pairs r Neisseria: kidney shaped diplococci

Bacteria morphology Staphylococcus : grape-like irregular clusters Streptococcus : chains or pairs Neisseria : kidney￾shaped diplococci

Bacteria culture: pigmentation r The bacteria produces liposoluble pigments which make the colonies appear in certain color. e Staphylococcus aureus golden yellow o Staphylococcus epidermidis white e Staphylococcus saprophyticus white or lemon vellow

Bacteria culture: pigmentation The bacteria produces liposoluble pigments which make the colonies appear in certain color: Staphylococcus aureus golden yellow Staphylococcus epidermidis white Staphylococcus saprophyticus white or lemon yellow

Bacteria culture: mannitol fermentation r Biochemical reactions for example, staphylococcus aureus is capable of using sugar mannitol(甘露醇) as a food source and will produce acidic byproducts of Staphylococcus aureus, Staphylococcus epidermidis, fermentation that wi‖l Streptococcus pneumoniae and Streptococcus pyogenes on mannitol salt agar plates(containing lower the ph of the 7.5% NaCl, mannitol and phenol red) media

Bacteria culture: mannitol fermentation Biochemical reactions: for example, Staphylococcus aureus is capable of using sugar mannitol (甘露醇) as a food source and will produce acidic byproducts of fermentation that will lower the pH of the media. Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae and Streptococcus pyogenes on mannitol salt agar plates (containing 7.5% NaCl, mannitol and phenol red)

Diseases 1. Ent (nasal or mucosal 3. Diseases wounds Stye L V. drug abuse) Boil, carbuncle 4. Exit Impetigo Endocarditis Pneumonia 2. Spread Emesis Diarrhea Toxic shock and bladder intections Suppurative infections Rash (scalded skin syndrome) )(化脓性感染) Genito L. Toxicoses Osteomyelitis urinary 毒素性疾病

I. Suppurative infections (化脓性感染) II. Toxicoses (毒素性疾病) Diseases