浙江大学医学院：《药理学 Pharmacology》课程教学资源（PPT讲稿）药物治疗学基础（Pharmacological basis of drug therapeutics）

第六编 药物治疗学基础 Section VI Pharmacological basis of drug therapeutics

General principles General Concepts History The Nature of Drugs Methodology of Pharmacology New Drug Research and Development

General Concepts Human disease: prevention and treatment Drug therapy Surgery Radiotherapy Physical therapy Psychological therapy 药理学是药物治疗学的基础理论

General Concepts Pharmacology can be defined as the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. Medical Pharmacology is often defined as the science of substances used to prevent, diagnose, and treat disease. Katzung BG(Ed). Basic Clinical Pharmacology(1lth Edition). New York: Mcgraw-Hill. 2010 药理学是研究药物与机体(包括人体和病原体)相互作用的规 律及其原理,是一门为临床合理用药防治疾病提供基本理论的 医学基础学科

Katzung BG (Ed). Basic & Clinical Pharmacology (11th Edition). New York: McGraw-Hill, 2010

What is Pharmacology studied? Pharmacodynamics(药效动力学,药效学): the actions of the drug on the body and the mechanisms Pharmacokinetics(药代动力学,药动学): the actions of the body on the drugs factors(影响因素): influencing the processes of pharmacodynamics and pharmacokinetics

Human Drugs pharmacodynamics(药效学)Bo av Action and mechanism Pharmacokinetics(药动学) Absorption, distribution, metabolism, excretion, and drug concentration in the body Interaction between drug and human body 药物与人体的相互作用

Drug Pathogens Human Interactions between drug, human body, and pathogens 药物、人体和病原体之间的相互作用

The Goals of Pharmacology Therapeutics Clinical 治疗学 Pharmacology Pharmacy Pharmacology Basic Research life se cience 药学 药理学 基础研究 Drugs New Drug Screening and 新药研制 E valuation

Pharmacology

History Remedies in China and Egypt, recognized and recorded the beneficial and toxic effects of many plant and animal materials. >2500 years ago l7 th century一本草学 Materia medica, the science of drug preparation and the medical use of drugs: the precursor pharmacology. End of 17th cetury 18th century—药物学

2 History Traditional pharmacology: developing the methods of experimental physiology and pharmacology; advances in chemistry. 18th century early of 20th century.—经典药理学 Modern pharmacology: concepts of rational therapeutics, especially that of the controlled clinical trials; a major expansion of research efforts in all areas of biology, 20th century rapid growth of information and understanding of the molecular basis for drug action, last 3 decades 现代药理学