浙江大学医学院：《药理学》课程教学资源（PPT讲稿）肾上腺素受体拮抗药 Adrenoceptor Antagonists

Chaper 20 Adrenoceptor Antagonists 1.areceptor antagonists 2.B receptor antagonists 3.a,B receptor antagonists

Chaper 20 Adrenoceptor Antagonists 1. αreceptor antagonists 2.  receptor antagonists 3. α,  receptor antagonists

AAdrenergic blockers have no effect on the actions of isoproterenol which is a pureβ agonist Pre treatment,:treatment Catecholamine Untreated with an“ya ontrol isoproterenol mm Ha 200 Epinephrine 200 Norepinephrine C-Adrenergic blockers reverse the vaso- constrictive action of epinephrine Epinephrine reversal(肾上腺素作用的圈转

Epinephrine reversal （肾上腺素作用的翻转）

1. at receptor antagonists I 1-1 a1 a receptor antagonists 0 Short-acting Phentolamine酚妥拉明 CH3 N——CH2 HO

1.  receptor antagonists 1-1 1 , 2 receptor antagonists Short-acting Phentolamine 酚妥拉明 N N CH3 HO N CH2 H

1. at receptor antagonists 口1 Pharmacology 口(1) Vasodilatation u Blocking a,receptor I (2)Stimulating heart 口 Reflex; blocking a2 receptor NE release个 D 3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, n个 0 Gastric acid secretion

1.1 Pharmacology (1) Vasodilatation Blocking 1 receptor (2) Stimulating heart Reflex；blocking 2 receptor ～NE release  (3) Cholinergic and histamine-like effects Contraction of GI smooth muscles, Gastric acid secretion  1.  receptor antagonists

1. at receptor antagonists 日1.2 Clinical uses o()Peripheral vascular diseases Acrocyanosis, Raynauds disease D (2) Local vasoconstrictor extravasation

1.2 Clinical uses (1) Peripheral vascular diseases Acrocyanosis, Raynaud’s disease (2) Local vasoconstrictor extravasation 1.  receptor antagonists

1. at receptor antagonists D (3) Shock 口 cardiac output↑; d redistribution of blood flow. D shift of fluid from interstitial compartment to vascular compartment; 口 pulmonary pressure↓; u fully adequate replacement of intravascular fluid

(3) Shock cardiac output ; redistribution of blood flow; shift of fluid from interstitial compartment to vascular compartment; pulmonary pressure ; fully adequate replacement of intravascular fluid 1.  receptor antagonists

1. at receptor antagonists D (4) Acute myocardial infarction and congestive heart failure after -load v 口 cardiac output个 a (5)Pheochromocytoma I pre-and post-operation 口 diagnosis I (6) Others: impotency

(4) Acute myocardial infarction and congestive heart failure after-load  cardiac output  (5) Pheochromocytoma pre- and post-operation diagnosis (6) Others: impotency 1.  receptor antagonists

1. at receptor antagonists 口1.3 Adverse effects I ()Postural hypotension D(2) Reflex heart stimulation D tachycardia, arrhythmia, angina pectoris 口3) GI reactions u(4Other central depression

1.3 Adverse effects (1) Postural hypotension (2) Reflex heart stimulation tachycardia, arrhythmia, angina pectoris (3) GI reactions (4) Other central depression 1.  receptor antagonists

1. at receptor antagonists 口T0 lazoline妥拉唑啉 weak effects more severe adverse effects

Tolazoline 妥拉唑啉 weak effects more severe adverse effects 1.  receptor antagonists

1. at receptor antagonists Long-acting Phenoxybenzamin酚羊明」 Longer action duration used for peripheral vasculardiseases anti-shock 口口口 pheochromocytoma improving urinary flow in patients with benign prostatic hypertrophy

Long-acting Longer action duration used for peripheral vasculardiseases anti-shock pheochromocytoma improving urinary flow in patients with benign prostatic hypertrophy Phenoxybenzamine 酚苄明 1.  receptor antagonists