浙江大学医学院：《药理学》课程教学资源（PPT讲稿）作用于血液及造血器官药物 Drugs acting on circulation system and blood / blood-forming organs

Drugs acting on circulation system and blood / blood￾forming organs

capillaries Pulmonar Pulmonary circulation artery Pulmonary voing Aorta Cardiovascular sysem arton) System 15 wein Systemic circulation Systemic Venules Arteriole Smaller arteries branching ofl Tissues to supply lout lie

Cardiovascular System

Overview of Cardiovascular System 0 Common Cardiac Diseases D Abnormal contractility Heart failures I Abnormal rhythms: Arrhythmias D Abnormal blood supply Ischemic heart diseases B Myocardial disorders a Common vascular diseases D Abnormal systematic resistance Hypertension u Dysfunction of coronary vessles: Coronary vascular diseases D Dysfunction of cerebral vessles: Cerebral ischemia, hemorrhage I Dysfunction of pulmonary vessles: Pulmonary hypertension I Dysfunction of peripheral vessles: Peripheral vasculardisorder n Arteriosclerosis

Overview of Cardiovascular System Common Cardiac Diseases Abnormal contractility：Heart failures Abnormal rhythms：Arrhythmias Abnormal blood supply：Ischemic heart diseases Myocardial disorders Common vascular diseases Abnormal systematic resistance：Hypertension Dysfunction of coronary vessles：Coronary vascular diseases Dysfunction of cerebral vessles：Cerebral ischemia, hemorrhage Dysfunction of pulmonary vessles：Pulmonary hypertension Dysfunction of peripheral vessles: Peripheral vascular disorder Arteriosclerosis

Overview of Cardiovascular Drugs u Classification based on target organs D Heart: Heart failures, arrhythmias, cardiac ischemia, over-oad of the heart 0 Vessels: Vasodilatation, vasoconstriction, arteriosclerosis o Classification based on the mechanisms D Ion channels: Ca2+ Na. K+channels I Receptors: Adrenoceptors, AT receptors, etc. 口 Enzymes:ACEI、Nat+K- ATPase、 HMG-CoA reductase a Others. Diuretics

Overview of Cardiovascular Drugs Classification based on target organs Heart：Heart failures, arrhythmias, cardiac ischemia, over-load of the heart Vessels：Vasodilatation, vasoconstriction, arteriosclerosis Classification based on the mechanisms Ion channels：Ca2+, Na+ , K+ channels Receptors：Adrenoceptors, AT receptors, etc. Enzymes：ACEI、Na+ -K+ -ATPase、HMG-CoA reductase Others：Diuretics

Drugs affecting ion channels in CVS 细扎外 内 L状

Drugs affecting ion channels in CVS

A General properties of ion channels in CVS I Properties of ion channels Permeation Selectivity u Gating voltage-gated chemically gated: ligand-gated 口口口口 cyclic nucleotide-gated mechanosensitive nongated background /leak channels

A. General properties of ion channels in CVS Properties of ion channels Permeation Selectivity Gating voltage-gated chemically gated: ligand-gated cyclic nucleotide -gated mechanosensitive nongated background / leak channels

on transmembrane Phospholipid transpor Extracelular 0000000000 Cytoplasmic

Ion transmembrane transport

Closed Open A Ligand-gated V Bind hgand Extracellular d Cytoplasmic B Phosphorylation gated Gating mechanisms of ion channels Dephosphorylate C Voltage-gated Change D Stretch or pressure- gated Stretch Cytoskeleton

Gating mechanisms of ion channels

A General properties of ion channels in CVS D Voltage-gated ion channels u Nat channels 口Ca2+ channels 囗K+ channels

A. General properties of ion channels in CVS Voltage-gated ion channels Na+ channels Ca2+ channels K+ channels

Voltage sensor c B 234586 l,Ⅳ Structure of SS1-SS2 a-subunit

Structure of α-subunit Voltage sensor