复旦大学：《皮肤病学 Dermatology》课程教学资源（PPT课件）性传播疾病 Sexually transmitted diseases（1/2）

Sexually transmitted diseases-part1 Lianjun Chen Huashan Hospital

Sexually transmitted diseases-part1 Lianjun Chen Huashan Hospital

Introduction The term venereal diseases"was historically used, now referred to as sexually transmitted diseases (STDs)or"sexually transmitted infections"(STIs) A group of diseases which are mainly spread by sexual contact, although other routes, such as blood transfusion and horizontal transmission, are not uncommon。 Classical STD: syphilis, gonorrhea, chancroid, lymphogranuloma venereum, and granuloma Inguinale

Introduction The term “venereal diseases” was historically used, now referred to as “sexually transmitted diseases” (STDs) or “sexually transmitted infections” (STIs) A group of diseases which are mainly spread by sexual contact, although other routes, such as blood transfusion and horizontal transmission, are not uncommon. Classical STD : syphilis, gonorrhea, chancroid, lymphogranuloma venereum, and granuloma inguinale

Sexually transmitted and transmissible pathogens Bacteria Neisseria gonorrhoeae Treponema pallidum Haemophilus ducreyi Chlamydia trachomaris Mycoplasma hominis, M. genitalium Ureaplasma urealyticum Gardnerellavaginalis Atopobium vaginae Mobiluncus curtisii, m. mulieris Klebsiella(Calymmatobacterium) granulomatis Shigella spp Campylobacter spp. Helicobacter cinaedi, h. fennelliae

Sexually transmitted and transmissible pathogens Bacteria – Neisseria gonorrhoeae – Treponemapallidum – Haemophilus ducreyi – Chlamydia trachomatis – Mycoplasmahominis, M. genitalium – Ureaplasmaurealyticum – Gardnerellavaginalis – Atopobium vaginae – Mobiluncus curtisii, M. mulieris – Klebsiella (Calymmatobacterium) granulomatis – Shigella spp. – Campylobacter spp. – Helicobacter cinaedi, H. fennelliae

Virus Human immunodeficiency virus, types 1 and Herpes simpler virus, types 2>1 Human papillon Hepatitis viruses, B>C and (via fecal-oral contact)A Cytomegalovirus Molluscum contagiosum virus Human T-cell leukemialymphotrophic virus, types I and II Human herpesvirus, type 8 Protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia Fungi Candida albicans Ectoparasites Phthirus pubis, Sarcoptes scabiei

Virus – Human immunodeficiency virus, types 1 and 2 – Herpes simplex virus, types 2 > 1 – Human papillomavirus – Hepatitis viruses, B > C and (via fecal-oral contact) A – Cytomegalovirus – Molluscum contagiosumvirus – Human T-cell leukemia/lymphotrophic virus, types I and II – Human herpesvirus, type 8 Protozoa – Trichomonas vaginalis,Entamoeba histolytica,Giardia lamblia Fungi – Candida albicans Ectoparasites – Phthirus pubis, Sarcoptes scabiei

Five most common std gonorrhea nongonococcal urethritis condyloma acuminatum genital herpes syphilis

Five most common STD – gonorrhea – nongonococcal urethrites – condyloma acuminatum – genital herpes – syphilis

GONORRHEA

GONORRHEA

Definition Gonorrhea is referred to as purulent infection due to Neisseria gonorrhoeae, which mainly occurs in urogenital system, but may also present as gonorrheal ophthalmia, pharyngitis, rectitis, pelvic inflammation or disseminated infection

Definition Gonorrhea is referred to as purulent infection due to Neisseria gonorrhoeae, which mainly occurs in urogenital system, but may also present as gonorrheal ophthalmia, pharyngitis, rectitis, pelvic inflammation or disseminated infection

Etiology Pathogen is Neisseria gonorrhoeae, calling diplococcus gonorrhoeae or gonococcus for short, first found in stained smears from vaginal, urethral and conjunctival exudates in 1879 by Albert Neisser In acute phase of the infection, the pathogens are detected in cytoplasm of leukocytes in the discharges of the patients, while in chronic phase, extracellular gonorrhoeae are more often seen

Etiology Pathogen is Neisseria gonorrhoeae, calling diplococcus gonorrhoeae or gonococcus for short, first found in stained smears from vaginal, urethral and conjunctival exudates in 1879 by Albert Neisser. In acute phase of the infection, the pathogens are detected in cytoplasm of leukocytes in the discharges of the patients, while in chronic phase, extracellular gonorrhoeae are more often seen

Morphology and Staining The gonococcus is a Gram-negative, diplococcal, pink bacterium appearing kidney or lima bean shape

Morphology and Staining： The gonococcus is a Gram-negative , diplococcal, pink bacterium ,appearing kidney or lima bean shape

Growth property For optimal growth, it requires a moist medium with temperature of 35 C-36C, and a 3-5%co2 atmosphere Gonococcus is fastidious organism that grow well in culture media including animal protein gonococcus die easily in dry and hot circumstances normal disinfectant or soap can cause it lose motoricity a Biochemical event Gonococcus can create oxidase during growing process, so oxidase test is meaningful in initial diaganosis

Growth property • For optimal growth, it requires a moist medium with temperature of 35 ℃ -36 ℃, and a 3–5% CO2 atmosphere. • Gonococcus is fastidious organism that grow well in culture media including animal protein. • Gonococcus die easily in dry and hot circumstances • Normal disinfectant or soap can cause it lose motoricity. Biochemical event • Gonococcus can create oxidase during growing process, so oxidase test is meaningful in initial diaganosis