复旦大学：《医学英语——学术医学英语口语》学生汇报_Unit 1 Stress and Stress-related Diseases_stress-related pathway

STRESS-RELATED PATHWAY 1307110302ZQ

11307110302 ZQ

KEY WORDS ° Stress Ghrelin胃饥饿素 Growth hormone Amygdala杏仁核 Auditory fear conditioning Fear learning

• Stress • Ghrelin 胃饥饿素 • Growth hormone • Amygdala 杏仁核 • Auditory fear conditioning • Fear learning

Ghrelin- growth hormone axis Chronic stress Ghrelin个 Ghrelin receptors located in amygdala Growth hormone↑ Enhancement of fear learning

• Chronic stress • Ghrelin • Ghrelin receptors — located in amygdala • Growth hormone • Enhancement of fear learning Ghrelin- growth hormone axis

Sham Stressed Unstressed ADX surgery Group A Group B Group C Group D

Stressed Unstressed ADX Sham surgery Group A   Group B   Group C   Group D  

100 Statistical significance Indicating ghrelin is taking a role NS STR NS STR SHAM ADX ≤1 NS STR NS STR SHAM DX AD

Statistical significance • Indicating ghrelin is taking a role

Long-term pharmacological stimulation of ghrelin receptor activity in unstressed ats b 100 80 60 40 L 24h24h24h 20 Test VEH: 5d MK: 5d MK0677 VEH: saline(生理盐水)

Long-term pharmacological stimulation of ghrelin receptor activity in unstressed rats. MK-0677: a ghrelin receptor agonist VEH: saline (生理盐水)

Ghrelin receptor antagonism during chronic stress abolishes stress-related enhancement of fear memory. 100 60 N 840 20 0 VEH DLyS3 VEH DLyS3 NS STR

• Ghrelin receptor antagonism during chronic stress abolishes stress-related enhancement of fear memory

THANK YOU! Q&A Figures from [A ghrelin-growth hormone axis drives stress-induced vulnerability to enhanced fear]

THANK YOU! Q&A Figures from [A ghrelin–growth hormone axis drives stress-induced vulnerability to enhanced fear]