河南师范大学：《生物化学》课程PPT教学课件（英文版）Section E Membranes

E Membranes E1 Membrane lipids E2Membrane protein and carbohydrate E3 Membrane transport: small molecules E4. Membrane transport: macromolecules E5.Signal transduction

• E1.Membrane lipids • E2.Membrane protein and carbohydrate • E3.Membrane transport:small molecules • E4.Membrane transport:macromolecules • E5.Signal transduction E Membranes

E1 Membrane lipids Membranes Membrane lipids Fatty acid chains Lipid bilayer Membrane fluidity Fluid mosaic model of membrane structure

Membranes Membrane lipids Fatty acid chains Lipid bilayer Membrane fluidity Fluid mosaic model of membrane structure E1 Membrane lipids

Membrane Membranes form boundaries around the cell and around distinct subcellular compartments. They act as selectively permeable barriers and are involved in signaling processes. All membranes contain varying amounts of lipid and protein and some contain small amounts of carbohydrate

Membrane • Membranes form boundaries around the cell and around distinct subcellular compartments. • They act as selectively permeable barriers and are involved in signaling processes. • All membranes contain varying amounts of lipid and protein and some contain small amounts of carbohydrate

Membrane 272 Outer face Phospholipid Fatty acyl Carbohydrate moiety Cholesterol Inner face

Membrane

Membrane lipids Three major classes of lipids 1. The glycerophospholipids,甘油磷脂 2. The sphingolipids鞘脂 3. The sterols胆固醇

Membrane lipids Three major classes of lipids: 1. The glycerophospholipids,甘油磷脂 2. The sphingolipids鞘脂 3. The sterols胆固醇

Membrane lipids Outer face of bilayer Total phospholipid 50 Sphingomyelin 30 Phosphatidylcholine 20 答10 20 Phosphatidylethanolamine Phosphatidylserine oO Phosphatidylinositol Inner face of bilayer

Membrane lipids

容| Triacylglycerol三酰甘油 CHCH 互o OH OH Glycerol ICH CH -CH 1-Stearoyl, 2-linoleoyl, 3-palmitoyl glycerol a mixed triacylglycerol

Triacylglycerol三酰甘油

Phosphatidylcholine磷脂酰胆碱 CHe CH. 0=P-O CH O CH CHo-o CH-N—CH2 CHs Phosphatidylcholine

Phosphatidylcholine磷脂酰胆碱

Phosphatidate R Acyl groups C CH 2 with fatty acid hydrocarbon chains R 0O-C-H o H2O Phosphatidate (Diacylglycerol 3-Phosphate)

Phosphatidate

Glycerophospholipids 00-C oo HC NHs HC CH Coo Phosphatidyl serine Phosphatidyl choline 0 O-C-H o R OO- H O HC NH3+ HC hosphatidyl ethanolamine hosphatidyl inositol HC 00—c-HO HC Diphosphatidyl glycerol (cardiolipin)

Glycerophospholipids