河南师范大学：《生物化学》课程PPT教学课件（英文版）Section F DNA structure and replication

F DNA Structure and replication 1. DNA structure 2. Chromosomes 3. DNA replication in bacteria 4. DNA replication in eukaryotes

1. DNA structure 2. Chromosomes 3. DNA replication in bacteria 4. DNA replication in eukaryotes F DNA structure and replication

F1 DNA structure Bases碱基 Nucleosides核苷 Nucleotides核苷酸 3,5′- phosphodiester bonds磷酸二酯键 DNA sequence dNA double helix

• Bases碱基 • Nucleosides核苷 • Nucleotides核苷酸 • 3’,5’- phosphodiester bonds磷酸二酯键 • DNA sequence • DNA double helix F1 DNA structure

Acid B ase Adenine Monophosphate Guanine Purine Diphosphate Sugar Thymine Triphosphate Pentose/ Cytosine Pyrimidine 2’ Uracil Ribose Deoxyribose Nucleoside(Adenosine Nucleotide(Adenosine monophosphate, AMI

Base Sugar Acid Monophosphate Diphosphate Triphosphate Adenine Guanine Thymine Cytosine Uracil Nucleoside (Adenosine) Nucleotide (Adenosine monophosphate, AMP) Purine Pyrimidine Ribose, Deoxyribose 1’ 3’ 2’ 4’ 5’ Pentose

Pyrimidines嘧啶 N Uracil Thymine Cytosine L NH NH U C T

1 2 3 4 5 6 Uracil NH N H O O U N N H NH2 O Cytosine C NH N H O O Thymine T Pyrimidines嘧啶

Purines嘌呤 N H N ● Adenine腺嘌呤 NH 2 ● Guanine鸟嘌呤 NH H NH2 A

1 2 3 4 5 6 9 7 8 N N N H N NH2 ⚫Adenine腺嘌呤 A NH N N H N O NH2 ⚫Guanine鸟嘌呤 G Purines嘌呤

Bases H 5 N N PURINES 24 8)-H 3 N H2N H H H Purine Adenine Guanine N N PYRIMIDINES 2;6 H N H rimini Cytosine Uracil Thymine

Bases

Ribose and deoxyribose H HO C OH H 2 HO OH bose HO OH H 2 HO Deoxyribose

Ribose and deoxyribose

Nucleosides核苷 C1:N1 C1:N9 N 5 8 6 3 1on2o、N HOCH 4K H Bm6 1 2 H OH H(OH) OH H(OH)

Nucleosides核苷 1’ 3’ 2’ 4’ 5’ (OH) 1’ 3’ 2’ 4’ 5’ (OH) C1 : N1 C1 : N9

假尿苷() c5:c1 HOCH H H OH OH

假尿苷（ψ） C5:C1 5 OH

Nucleosides NH OH NH2 oH N HON N HO N HO N HOCH2 O HOCH HOQ2 O HOCHO O HH HH H H H H H OH OH OHOH OHOH OHOH 腺嘌呤核苷鸟嘌呤核苷 胞嘧啶核苷 尿嘧啶核苷 Adenosine Guanosine Cytidine Uridine

Adenosine Guanosine Cytidine Uridine Nucleosides 腺嘌呤核苷 鸟嘌呤核苷 胞嘧啶核苷 尿嘧啶核苷 N N OH HO N N NH2 HO N N OH H2N N N N N N N NH2 O H H OH H OH H HOCH2 HOCH2 O H H OH H OH H O H H OH H OH H HOCH2 O H H OH H OH H HOCH2