复旦大学：《传染病学 Infectious diseases》课程教学资源（课件讲稿）立克次氏体 Rickettsia

RICKETTSIA ORIENTIA EHRLICHIA ANAPLASMA COXIELLA Jialin jir BARTONELLA Fudan university huashan hospital Department of infectious diseases 2014 NoV

RICKETTSIA ORIENTIA EHRLICHIA ANAPLASMA COXIELLA Jialin Jin BARTONELLA Fudan university huashan hospital Department of infectious diseases 2014 Nov

General introduction a气, Gram-negative, obligate intracellular coccobacilli bacteria that infect mammals and arthropods Rickettsiae are transmitted in the arthropods, which serves as both vector and reservior Both dna and rna Is sensitive to antibiotic Culture: in animate media

General introduction  Gram-negative, obligate intracellular coccobacilli bacteria that infect mammaols and arthropods  Rickettsiae are transmitted in the arthropods,which serves as both vector and reservior  Both DNA and RNA  Is sensitive to antibiotic  Culture：in animate media

Anthropods. ticks, mites. lice, and fleas Tick扁虱 Mite螨虫 live lous Live louse Flea跳蚤 Louse虱子

Anthropods: ticks, mites, lice, and fleas Tick 扁虱 Mite 螨虫 Louse 虱子 Live louse Flea 跳蚤

Category of rickettsia a气, Genus Rickettsia. Coxie/la Orientia Ehrlichia Bartonella Species Rickettsia prowazeki(epidemic typhus) Rickettsia typhi(endemic typhus), Rickettsia rickettsii(spotted fever), Rochalimaea quintana trench fever), Coxiella burneti(Q fever)

Category of rickettsia  Genus Rickettsia, Coxiella ,Orientia,Ehrlichia,Bartonella  Species Rickettsia prowazekii (epidemic typhus), Rickettsia typhi (endemic typhus), Rickettsia rickettsii (spotted fever), Rochalimaea quintana (trench fever), Coxiella burnetii (Q fever)

Biological features Variable shape, coccobacilli Gram negative Microcapsule and slime < laver 民 Culture: in york sacs of embryonated eggs

Biological features  Variable shape, coccobacilli  Gram negative  Microcapsule and slime layer  Culture : in york sacs of embryonated eggs

Antigenic structure a气, ■LPS Rickettsia tsutsugamushi CoXiella burnetii(Q fever LPS I Smooth LPSI roug h Weil-Felix reaction a Surface protein(SPA)

Antigenic structure  LPS Rickettsia tsutsugamushi Coxiella burnetii (Q fever) LPSⅠ smooth LPSⅡ rough Weil-Felix reaction  Surface protein(SPA)

Transmission a Typhus, spotted fever and trench fever are transmitted via arthropod vectors aQ fever is acquired via inhalation or ingestion of contaminated milk or food

Transmission  Typhus, spotted fever and trench fever are transmitted via arthropod vectors;  Q fever is acquired via inhalation or ingestion of contaminated milk or food

Pathogenesis: vasculitis Virulence factors endotoxin phospholipase A, and slime layer Sites: vascular system producing vasculitis 血管炎 Characteristic triad of symptoms fever, headache and rash(no rash with Q fever)

Pathogenesis：vasculitis  Virulence factors: endotoxin, phospholipase A, and slime layer  Sites: vascular system producing vasculitis 血管炎  Characteristic triad of symptoms:  fever, headache and rash (no rash with Q fever)

Replication cycle of Rickettsia and Orientia ,二知 Rickettsia infection of an endothelial cell Phagocytosis is induced Lysis of cell: R prowazekii 0o→(。 Bacterium escapes from phagosome Filopodium focal lysis: R. rickettsii adding: R tsutsugamushi

Replication cycle of Rickettsia and Orientia

rickettsial family of diseases a气, a Four groups The spotted fever group The typhus group The Ehrlichia group Q fever

rickettsial family of diseases  Four groups  The spotted fever group  The typhus group  The Ehrlichia group  Q fever