中国人民解放军陆军军医大学（第三军医大学）：《生物科学——结构生物学》课程PPT教学课件_第一讲 结构生物学概述 Introduction of structural biology

研究生核心课程一一新兴学科与前沿技术 第一讲:结构生物学概述 Introduction of structural biology 刘威 第三军医大学全军免疫研究所 Te:02368771962 weiliu2013@icloud.com

第一讲：结构生物学概述 Introduction of structural biology 刘威 第三军医大学全军免疫研究所 Tel: 023-68771962 wei.liu.2013@icloud.com 研究生核心课程－－新兴学科与前沿技术

参考教材 生命科学名著 TEXTBOOK ON STRUCTURAL EG BIELOGY Anders Liljas, Lars Liljas, Jure Piskur, Goran Lindblom Poul Nissen a Morten Kjeldgaard Textbook of Structural Biolo 结构生物学 从原子到生命 如 World Scientific

参考教材

§1结构生物学的研究对象

§1 结构生物学的研究对象

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眼见为实：从宏观到微观

In nature, organs are shaped as most useful tools in life aviary >> curricuum >> FeeD THe BIrDS Beaks are Tools ① acTIvITIes THe rigHt BeaK BACKGROUND For THe JOB What do these birds eat? These six birds will feed at the buffet you set up (next step) When you figure out the best tool for gathering the different foods, you can compare that tool to these pictures, and find A B out what each bird eats Imagine a flamingo trying to sip nectar, or a hummingbird trying to crack open nuts. They These six birds eat very different things. Their beaks are the perfect tool for the job Compare the beaks to the common tools you see here. You can tell alot about how a bird gathers its food by the shape of EGRET FLAMINGO HAWK HORNBILL HUMMINGBIRD PARROT A beak like a A slotted spoon Shears are good Tongs can grab A straw is perfect A nutcracker Ready to lean what each eats? knife is good for or strainer can for cutting meat things that are for sipping breaks open stabbing at food. filter things out of hard to reach hard shells p//www.aviary.com/curric/beaks.html

In nature, organs are shaped as most useful tools in life

And so are biomolecules MOLECULAR 您份 MACHINER A Tour of the Protein data Bank 霉 要里多 noEa, Dai tp://www.pdh.ars/.info@resb.err 1

And so are biomolecules

A protein called alpha-keratin forms your hair and fingernails. and also is the major component of feathers wool, claws, scales The hemoglobin protein carries horns, and hooves. oxygen in your blood to every part of your bod Muscle proteins called actin lon channel proteins control brain and myosin enable all muscular signaling by allowing small mole- movement-from blinking to G cules into and out of nerve cells breathing to rollerblading Receptor proteins stud the out Enzymes in your saliva, stomach, side of your cells and transmit and small intestine are proteins signals to partner proteins on that help you digest food the inside of the cells Huge clusters of proteins form Antibodies are proteins molecular machines that do your that help defend your body cells heavy work, such as copy against foreign invaders, such ing genes during cell division and as bacteria and viruses making new proteins. httppublicationsnigmsnihgov/struclife